Experimental Compound NAF19 Blocks Key Growth Signals in Prostate Cancer Cells
A new laboratory study reports that the arylpiperazine derivative NAF19 suppresses proliferation, migration, invasion and survival signaling in five prostate ...
Tag: preclinical study
Silencing HIF-1α Makes Erlotinib Work Better Against Lung Cancer Cells
A new cell-line study reports that silencing HIF-1α with siRNA synergizes with erlotinib to suppress proliferation, invasion and glycolysis in ...
EZH2 Blockade Restores Glioblastoma Sensitivity to Radiotherapy in Preclinical Models
A new study reports that irradiation stabilizes EZH2 in glioblastoma, driving H3K27me3-mediated DEPTOR repression and mTOR activation, and that EZH2 ...
Sugar Tag on ASGR1 Protein Curbs Deadly Heart Damage in Sepsis
A sugar modification of the ASGR1 protein reduces septic heart injury in mice by blocking ZBP1-driven PANoptosis, according to a ...
Selenium Compound Shields Spinal Cord White Matter in Rats by Blocking Ferroptosis
In a rat model of contusive spinal cord injury, daily oral sodium selenite preserved oligodendrocytes and myelin and improved locomotor ...
Early Spinal Muscle Loss Emerges as Hidden Driver of Muscular Dystrophy
MRI studies of patients and dysferlinopathic mice reveal early fatty degeneration of spinal muscles driven by adipogenic progenitors, with GSK3 ...
Desipramine Blocks Neuronal Ferroptosis in Ischemic Stroke Mouse Model
A new mouse and cell study shows that inhibiting acid sphingomyelinase with desipramine lowers ceramide, curbs neuronal ferroptosis and reduces ...
Ultrasound-Triggered Nanoparticles Deliver Herbal Extract to Shield Irradiated Hearts
A preclinical study reports that cardiomyocyte-targeted, ultrasound-responsive nanoparticles delivering Abelmoschus manihot extract suppressed radiation-induced ferroptosis and preserved heart function in ...
Fragrance Compound Linalool Slows Gastric Cancer by Stabilizing NR3C2 Protein
A new Cell Division study reports that linalool stabilizes the NR3C2 protein in gastric cancer cells, activating NFKBIZ and suppressing ...
Traditional Chinese Medicine Formula Kangxianling Shows Anti-Fibrosis Effects in Rats by Suppressing Ferroptosis
A preclinical study reports that Kangxianling Decoction reduced renal fibrosis in a rat model by suppressing ferroptosis through the p53/GPX4 ...
Taurine-loaded nanoparticles combine photothermal therapy and immune modulation against gastric cancer in mice
Hyaluronic acid-modified taurine-polydopamine nanoparticles combined photothermal therapy with taurine-driven immune modulation to suppress gastric tumors in mice.
Terbium-161 Shows Dose-Dependent Edge Over Lutetium-177 in Mouse Neuroendocrine Tumor Model
In mice bearing SSTR2-H69 xenografts, terbium-161-labeled DOTA-TATE and DOTA-JR11 matched lutetium-177 at 20 Gy tumor dose and outperformed it at ...
Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
Telotristat Plus Everolimus Halts Tumor Growth in Neuroendocrine Cancer Models
A preclinical study reports that combining the serotonin-synthesis inhibitor telotristat ethyl with the mTOR inhibitor everolimus arrested tumor growth in ...
Fasting slows colorectal cancer growth in mice by triggering IRF7-driven metabolic and immune changes
A new Cellular Oncology study reports that short-term starvation suppresses colorectal cancer cells by upregulating IRF7, which downregulates PFKFB3, induces ...
Artesunate Shows Promise Against Rheumatoid Arthritis by Triggering Ferroptosis in Synovial Cells
A new preclinical study reports that artesunate suppresses activated synovial fibroblasts and eases collagen-induced arthritis in mice by inducing ferroptosis ...
Melatonin Analogue Shows Potent Anti-Breast Cancer Activity in Lab Tests
A synthetic melatonin analogue blocked the growth and migration of estrogen receptor-positive breast cancer cells in laboratory tests but failed ...
Dormant Until They Reach the Brain: Engineered CAR-T Cells Clear a Lethal Pediatric Tumor in Mice
UC San Francisco scientists engineered B-SYNC CAR-T cells that activate only in the brain and cleared diffuse midline glioma in ...
Natural Saponin Esculentoside A Curbs Liver Cancer Growth by Stabilizing RORB Protein
A new preclinical study reports that the plant-derived saponin esculentoside A suppresses hepatocellular carcinoma growth and stemness in cells and ...
Rosemary and Day Lily Blend Shows Antidepressant-Like Effects in Mice
A seven-day course of a rosemary and day lily herbal formulation reduced immobility in the forced swim test and preserved ...
