Engineered NK Cells Target CD73 to Attack Hard-to-Treat Lung Adenocarcinoma
Preclinical research shows that natural killer cells engineered with a CD73-targeting receptor kill relapsed or refractory lung adenocarcinoma cells in ...
Tag: preclinical study
Fasting-mimicking diet reshapes gut microbiota in mouse Lynch syndrome model
Periodic fasting-mimicking diet cycles reduced dysbiotic microbial shifts in mice modelling Lynch syndrome, without preventing tumour development.
Drug Repurposing Candidate Ebselen Boosts Mitochondrial Function Across Disease Models
A preclinical study reports that the organoselenium compound ebselen improved mitochondrial respiration, ATP production and exercise capacity in yeast, human ...
Trapezoidal Magnetic Fields Boost Nanoparticle Hyperthermia Against Tumors in Mice
In a mouse glioblastoma model, trapezoidal pulsed magnetic fields made nanoparticle hyperthermia shrink tumors while sinusoidal fields did not.
Blocking IL-6 Trans-Signaling Protects the Heart in Mouse Sepsis Study
A mouse and cell study reports that the IL-6 trans-signaling inhibitor sgp130Fc improved cardiac function and survival in sepsis-induced myocardial ...
Ferulic Acid Niosomes Shield Rat Testes from Chemotherapy Damage in Preclinical Study
A rat study found that ferulic acid loaded into niosomes outperformed the free compound in reducing doxorubicin-induced testicular damage across ...
Nitazoxanide Delivered in Chitosan Nanoparticles Cuts Oocyst Burden in Mice with Cryptosporidiosis
A mouse study found that nitazoxanide loaded into chitosan nanoparticles reduced fecal and intestinal Cryptosporidium oocyst counts more than free ...
Cannabidiol Injections Reshape the Gut Microbiome in Mice, Study Finds
Daily injections of pure CBD altered the duodenal microbiome of mice in a seemingly dose-dependent pattern over a 28-day experiment.
Caloric Restriction Makes Colorectal Tumors More Vulnerable to Radiation in Mice
In a mouse and cell study, caloric restriction and fasting enhanced radiation's tumor-killing effects through the cGAS-STING pathway while protecting ...
Boiled and Finely Ground Balsam Apple Leaf Powder Lowers Cholesterol in Rats
A rat study found that cooking and sieving Momordica balsamina leaf powder into fine fractions improved its extractable polyphenol content ...
After Brain Injury, Astrocytes Ship Mitochondria to Struggling Neurons
A mouse study of traumatic brain injury found that astrocytes increase mitochondrial transfer to neurons via extracellular vesicles, a response ...
New PSMA-Targeted Radioligand Shows Stronger Tumor Uptake Than Lu-PSMA-617 in Mice
In preclinical LNCaP mouse models, the novel PSMA-targeted radioligand Lu-M3-12 showed higher tumor uptake and a better tumor-to-kidney ratio than ...
Push or Block: Both Directions of PKM2 Activity Kill Leukemia Cells
A new study shows that both inhibiting and activating the metabolic enzyme PKM2 reduces nuclear accumulation of the protein, lowers ...
Prostaglandin E2 Reverses Prostate Enlargement in Rats, Rivaling Finasteride
In a rat model of testosterone-induced benign prostatic hyperplasia, oral dinoprostone prevented prostate enlargement and suppressed proliferative, inflammatory and fibrotic ...
Glucose-Eating Nanoparticle Fires Up Two Cell-Death Pathways to Fight Tumors
A three-component nanoparticle that consumes tumor glucose and triggers pyroptosis and cuproptosis suppressed liver cancer growth and established immune memory ...
Quercetin Plus Low-Dose Gamma Rays Curbed Chemically Induced Liver Cancer in Rats
In a rat model of chemically induced liver cancer, combining oral quercetin with fractionated low-dose gamma irradiation outperformed either treatment ...
Plant-Derived Nanoparticles From a Medicinal Herb Trigger Ferroptosis in Liver Cancer Models
Nanoscale vesicle-like particles isolated from the medicinal herb Selaginella doederleinii suppressed liver cancer cells and tumors in mice by inducing ...
Starving Ovarian Cancer Cells of Cysteine May Boost Carboplatin Response
Preclinical experiments show that depriving ovarian cancer cells of cyst(e)ine, or blocking its metabolism with drugs, enhances their responsiveness to ...
Saikosaponin A Shows Promise for Diabetic Wound Healing in Mouse Study
In a preclinical study, saikosaponin A accelerated wound closure in diabetic mice and was associated with suppressed macrophage pyroptosis and ...
Kaempferol Eases Muscle Wasting in Mice With Cancer Cachexia
A study combining bibliometric mining, network pharmacology and mouse experiments identified the plant flavonoid kaempferol as a candidate compound against ...
