Preclinical Meta-Analysis Evaluates Escin and Nanoformulations Against Cancer Growth
A systematic review of 34 preclinical studies indicates that escin and its nanoformulations significantly inhibit cancer cell growth and reduce ...
Tag: preclinical study
Mitochondrial uncoupler BAM15 shields mice from acute lung injury by calming STING inflammation
In a mouse study, the mitochondrial uncoupler BAM15 improved survival and eased lipopolysaccharide-induced acute lung injury by preserving mitochondrial integrity, ...
Soluble PD-1 emerges as biomarker and therapeutic target in lupus nephritis
A multicenter study links elevated soluble PD-1 to lupus nephritis severity and shows that neutralizing it improves kidney outcomes in ...
Small Molecule PET Tracer Penetrates Brain But Lacks Specificity
A new carbon-11 labeled small molecule penetrates the blood-brain barrier but fails to show specific GLP-1R binding in preclinical PET ...
Dual-Tracer SPECT Approach Targets Prostate Cancer and Bone
The study, published in EJNMMI Radiopharmacy and Chemistry, utilized two distinct radiotracers: In-PSMA-I&T for targeting PSMA-positive lesions and Tc-DPD for ...
STING Agonist Cuts TNBC Tumor Recurrence and Extends Survival in Mice
Pharmaceutical STING activation reduced primary tumor recurrence and extended survival in a mouse model of metastatic triple negative breast cancer.
NFS1 Emerges as Stress-Induced Vulnerability When mTOR Is Suppressed in Glioblastoma
A new study shows that suppressing mTOR signaling in glioblastoma cells induces NFS1, a cysteine desulfurase that supports a stem-like ...
Liensinine targets ATG9B to curb autophagy dysfunction in PCOS models
Researchers found that the natural compound liensinine binds ATG9B to modulate AKT/mTOR signalling and reduce excessive autophagy in PCOS cell ...
Effect of peroxybenzoic acid and hydroxybenzoic acid on allergic asthma
A pair of common phenolic compounds that turn up everywhere from cosmetics to pharmaceutical synthesis have now been put head ...
MRI-Guided Blood Clot Filter Shows Promise in Animal Tests
A resonant inferior vena cava filter and snare loop were implanted and retrieved under 3 Tesla MRI guidance in pigs, ...
Low-oxygen conditioning of transplant recipients extends heart graft survival in mice
A mouse study finds that conditioning transplant recipients, not donors, under chronic hypoxia prolongs heart allograft survival through a HIF2-dependent ...
Notch ligand DLL1 shields ovarian cancer cells from ferroptosis, fueling cisplatin resistance
A preclinical study reports that the Notch ligand DLL1 activates an Nrf2/GPX4 antioxidant axis that suppresses ferroptosis and weakens cisplatin's ...
Fructus Gardeniae restores gut microbiota and short-chain fatty acids to ease acute pancreatitis in mice
A new mouse study shows that the medicinal herb Fructus Gardeniae protects against acute pancreatitis by restoring gut microbial balance ...
Chitosan-Coated Selenium Nanoparticles Loaded with Mucuna pruriens Extract Ease Parkinson-Like Symptoms in Rats
A new rat study reports that chitosan-coated selenium nanoparticles carrying Mucuna pruriens seed extract improved motor function, antioxidant levels, and ...
FLASH radiotherapy spares healthy astrocytes while stressing glioma cells
A new Cell Death Discovery study shows FLASH radiotherapy preserves mitochondrial function in healthy astrocytes while driving sustained redox and ...
Dual-Drug Liposomes With YIGSR Peptide Target Breast Tumor Cells in Mice
A YIGSR-modified liposome co-loaded with doxorubicin and 5F showed stronger cytotoxicity, higher cellular uptake and greater tumor accumulation than non-targeted ...
Plant Compound Ziyuglycoside I Speeds Wound Healing by Activating Immune Cells Through GPR34 Receptor
Ziyuglycoside I, a compound from Sanguisorba officinalis L., accelerated wound closure in mice by activating GPR34 signaling in group 3 ...
CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
CD276 Blockade Slows Gastric Cancer and Boosts Anti-PD-1 Immunotherapy in Preclinical Study
Blocking the CD276 molecule slowed gastric cancer growth and, combined with anti-PD-1 therapy, produced the strongest tumor suppression and increased ...
Fc-Free CLDN18.2 × CD3 Antibody AHT-102 Shrinks Gastric Tumors in Mice
A new Fc-free CLDN18.2 × CD3 bispecific antibody called AHT-102 showed dose-dependent tumor suppression, tumor-selective tissue distribution, and no systemic ...
