A large UK Biobank proteomics study finds that higher birth weight and breastfeeding are linked to slower biological aging across multiple adult organs, with cumulative stress burden partially mediating the effects.
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A mouse study reveals that endocannabinoid 2-AG signaling in the oval bed nucleus of the stria terminalis acts as a brake on PTSD-like social avoidance...
A Sutter Health virtual review board allowed general neurologists to safely prescribe and monitor amyloid-targeting Alzheimer's therapies in community settings, with 77 percent of reviewed...
A large UK Biobank proteomics study finds that higher birth weight and breastfeeding are linked to slower biological aging across multiple adult organs, with cumulative...
A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a tumor-promoting M2-like state.
A comprehensive review maps how strategic chemical modifications to the purine scaffold yield potent drug candidates against cancer, malaria, drug-resistant infections, viruses, and inflammatory disease.
A new iScience study integrates East Asian genetic variants with early treatment response data to predict which Graves' disease patients will fail standard antithyroid drug...
Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking tumors in mice.
A genomic study of nearly 3,000 Nunavut newborns reveals that three autosomal recessive conditions, including congenital sucrase-isomaltase deficiency at one in 28 live births, occur...
The first metagenomic and metabolomic survey of the orange-collared keelback reveals a shared core gut microbiome with segment-specific differences in microbial taxa, carbohydrate-degrading enzymes, and...
Researchers engineered 1,440 derivatives of an anti-Cryptosporidium compound and identified two potent lactate dehydrogenase inhibitors that clear the parasite in mice and calves while restoring...
Research into naturally parasite-resistant St. Croix sheep is revealing how an early Th2 immune response blocks the deadly blood-feeding worm Haemonchus contortus, offering a route...
A phenomenological study of ten midwives and obstetric nurses in Macao reveals how silence, fear and empathy shape grief care after stillbirth.
Researchers have built a deep reinforcement learning system called HE-FDDQN that personalizes college students' physical training with 92.5 percent accuracy while guarding against overtraining.
A new conserved-variable wellbore flow model quantifies how CO2 compressibility delays pressure transmission during fracturing and identifies pump rate as the dominant operational control.
A modelling study of more than 833,000 Mexican dengue cases reveals large spatial, temporal and serotype-specific differences in transmission intensity between 2016 and 2023, including...
