Butyrate Microspheres Boost Gut Butyrate and Ease Diabetes Signs in Mice
A colon-targeted sodium butyrate microsphere formulation raised fecal butyrate, lowered blood glucose and HOMA-IR, and reduced serum IL-6 in diabetic ...
Tag: preclinical study
ROS-responsive nanoparticle pairs PARP inhibitor with DOT1L blocker to fire up antitumor immunity in ovarian cancer models
A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...
Sex shapes radiation lung injury and drug response in rat study
A rat study found that biological sex modified both radiation-induced lung injury patterns and the effectiveness of enalapril, metformin and ...
Astragaloside IV Eases Fatty Liver by Epigenetically Silencing a Lipogenesis Switch
A new preclinical study reports that the Astragalus compound astragaloside IV reduces hepatic fat accumulation in mice and human liver ...
Berberine Eases Diabetic Kidney Damage by Tuning a Renal Sugar-Transport Switch
A preclinical study reports that berberine reduced kidney injury in diabetic mice and curbed glucose uptake in kidney cells through ...
Desert Plant Extracts Boost Diabetes Drug Effects in Diabetic Rats
In alloxan-induced diabetic rats, Ziziphus nummularia leaf and fruit extracts lowered blood glucose and improved lipids in a dose-dependent manner, ...
Approved cancer drug dabrafenib halts brain blood vessel malformations in mice
An already approved cancer drug, dabrafenib, reduced and stabilised cerebral cavernous malformations in mouse models, supporting its repurposing as a ...
Oral colchicine eases stiff shoulders and curbs scarring in rats with frozen shoulder
In a rat model of frozen shoulder, daily oral colchicine improved shoulder motion and reduced capsular fibrosis and inflammation, though ...
Pterostilbene Protects Rat Ovaries from Chemical Damage in Preclinical Study
Pterostilbene reduced inflammation, apoptosis, and oxidative DNA damage in rats with chemically induced ovarian insufficiency while strongly increasing SIRT1 and ...
Two-drug cocktail reprograms heart cells into an embryonic-like state to repair damage
A simplified two-compound drug cocktail, 2SM, promoted cardiomyocyte proliferation and improved heart function after myocardial infarction in rats and mice, ...
Engineered albumin carrier extends protein drug half-life and enables needle-free mucosal delivery
Researchers fused EPO to an engineered human albumin variant that binds FcRn more efficiently, extending its plasma half-life more than ...
Myricetin Targets HSP90AA1 to Curb Bladder Cancer Growth in Preclinical Models
A new multi-omics study reports that myricetin from Myrica rubra binds HSP90AA1, suppresses PI3K–Akt signaling and inhibits bladder cancer growth ...
Vaccine adjuvant AS01 induces trained immunity and slows tumor growth in mice
A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...
Ruxolitinib in cold storage solution preserves heart function in aged donor mice
Adding the senomorphic drug ruxolitinib to cold storage solution improved contractile recovery in hearts from aged mice, with stronger effects ...
3D-Printed Synthetic Tracheal Patch Keeps Rabbit Airways Open for 30 Days
A 3D-printed polyurethane-PVC scaffold maintained airway patency for 30 days in rabbits, though epithelial regeneration remained incomplete.
Computational agent pinpoints ADAM17 as drug target in biliary tract cancer
An AI-driven target discovery framework ranked ADAM17 first for biliary tract cancer, and antibody-drug conjugates and CAR-T cells built against ...
Young plasma vesicles rejuvenate aged mice, but key questions remain open
A new perspective examines how small extracellular vesicles from young plasma reversed multiple signs of ageing in male mice, while ...
Plasma exchange cuts amyloid plaques in aged Alzheimer’s model mice
A mouse study reports that monthly plasma exchange with albumin, started at an advanced stage of amyloid pathology, reduced insoluble ...
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
Experimental Antifungal ISFP10 Shows Potent Candida Activity and Safe Profile in Mice
The experimental compound ISFP10, which selectively inhibits a fungal-specific cell wall enzyme, showed potent activity against Candida strains in vitro ...
