How Glial Cells Determine Whether Parkinson’s Aggregates Clear or Propagate
A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...
Tag: neurodegeneration
Brain-derived vesicle profiling opens non-invasive window on Alzheimer’s in Down syndrome
Ultrasensitive profiling of neuron- and astrocyte-derived vesicles from plasma reveals stage-linked protein signatures of neurodegeneration, inflammation and vascular stress across ...
Circular RNA Protein Aβ175 Characterized In Silico in Alzheimer’s Study
A computational study from the University of Kalyani predicts the structural features of Aβ175, a protein encoded by the circular ...
TDP-43 Hijacks a Tankyrase Switch That Powers Proteasome Assembly and Axonal Transport
A new study shows that pathological TDP-43 sequesters tankyrase into insoluble complexes, disrupting PI31-mediated proteasome assembly and axonal transport in ...
Redox drugs for Huntington’s disease: why strong preclinical promise keeps failing in trials
A new narrative review finds that antioxidant and mitochondria-targeted compounds show consistent benefits in Huntington's disease models but have repeatedly ...
Choroid plexus emerges as key player in multiple sclerosis progression, systematic review finds
A systematic review synthesises preclinical and human evidence that the choroid plexus drives immune infiltration, barrier disruption and genomic changes ...
Corneal nerves under the microscope: a window on nerve damage in diabetes, Parkinson’s and beyond
A narrative review finds corneal nerve measurements taken with in vivo confocal microscopy show the strongest evidence as an adjunctive ...
Prior Herpes Simplex Encephalitis Linked to Lasting Memory Deficits and Brain Changes
A retrospective study of eleven patients found that previous herpes simplex virus type 1 encephalitis was associated with long-term episodic ...
MRI Tract Patterns Sort ALS Patients into Three Subtypes Linked to Disease Severity
A diffusion MRI analysis grouped 73 ALS patients into three white matter subtypes whose imaging-derived disease stages correlated with clinical ...
Neurons Do Not Die Alone: Why Neurodegeneration Is a Disease of the Tissue Around Them
A new PLOS Biology Editorial argues that neurodegeneration research must look beyond dying neurons to the glia, vasculature, immune signals ...
Sleep loss after brain injury boosts early Alzheimer-like protein changes in mice
A new mouse study shows that traumatic brain injury alone triggers early Alzheimer-like protein variant buildup in wild-type animals, and ...
Hidden Enzymes That Erase Protein Palmitoylation Emerge as Disease Drivers
A new review maps how ABHD enzymes regulate the reversible lipid modification S-palmitoylation and shape cancer, neurodegeneration, antiviral immunity and ...
CSF GFAP Rises Sharply With Age, New Reference Limits Show
A cross-sectional study of 325 screened Danish biobank participants establishes age-specific upper reference limits for Simoa-measured CSF GFAP, which rise ...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's ...
Retina’s Master Support Cells Take Center Stage in Blinding Disease
A new review argues that Müller glia, the retina's dominant support cells, actively shape retinal disease progression and may offer ...
People with Parkinson’s disease still read emotions from the way others walk
A study of 38 people with Parkinson's disease and 38 matched controls found that emotion recognition and valence ratings from ...
tRNA Fragments May Link Chronic Stress to Translation Failure in Alzheimer’s Disease
A new review proposes that tRNA-derived small RNAs link chronic cellular stress to maladaptive translational remodeling in Alzheimer's disease.
SAT1 Overexpression Eases Alpha-Synuclein Toxicity in Fly Model of Parkinson’s Disease
In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response ...
Cellular Stress Protein JWA Emerges as Context-Dependent Redox Hub in Aging and Disease
A new narrative review synthesizes how the multifunctional protein JWA intersects with redox homeostasis across cancer, neurodegeneration and tissue injury, ...
Peroxisomal Protein PEX11β Restores Mitochondrial Function and Behavior in Huntington’s Disease Mice
Restoring the peroxisomal fission protein PEX11β improved motor and cognitive deficits and mitochondrial gene expression in a toxin-induced mouse model ...
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