Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
Tag: neurodegeneration
Phase 2b trial of neflamapimod in dementia with Lewy bodies fails to replicate earlier promise
A phase 2b randomized trial found no benefit of neflamapimod on the primary CDR-SB outcome in dementia with Lewy bodies, ...
MRI study maps two sequences of brain barrier leaks and thinning in cognitive impairment
A SuStaIn analysis of DCE-MRI and structural MRI data from 216 participants identified atrophy-first and BBB-first subtypes with distinct cognitive ...
Circular RNA circSMOX Emerges as a Player in Muscle and Nerve Disease
A new mini review in Amino Acids summarizes what is known about the circular RNA circSMOX, which is upregulated in ...
Tea Catechins and Cocoa Flavanols May Complement Exercise in Brain Aging, Review Finds
A narrative review suggests green tea catechins and cocoa flavanols may support exercise-induced adaptations in brain aging through distinct mitochondrial ...
SOD1 Aggregates Injected into Brain Fluid Trigger ALS in Mice
Injecting two strains of misfolded human SOD1 aggregates into the cerebrospinal fluid of transgenic mice triggered prion-like aggregation and fatal ...
Src kinase emerges as a molecular player in early tau pathology in Alzheimer’s disease
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
ADP-ribose, an NAD+ catabolite, drives neuronal ferroptosis through ENT2 inhibition
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of ...
Astrocyte Lipid Metabolism Emerges as a Central Player in ALS Progression
A new review argues that disrupted lipid handling in astrocytes may amplify motor neuron injury and disease progression in ALS.
Blood–Brain Barrier Breakdown Speeds Alzheimer’s-Like Damage in Fruit Flies
Knocking down the receptor moody in Drosophila barrier glia increased permeability and, together with human amyloid-beta expression, worsened neurodegeneration without ...
MRI Brain Age After Traumatic Brain Injury: Systematic Review Finds Mixed, Hard-to-Compare Evidence
A new systematic review finds that MRI-derived brain age differences after adult traumatic brain injury are inconsistent across studies and ...
Light Therapy Works Only During Sleep in Aging Mouse Brains
A study in mice finds that near-infrared light therapy clears beta-amyloid and improves memory in aged animals only when delivered ...
Removing Prion Protein from Human Astrocytes Alters Reactivity and Mitochondria but Not Neuronal Support
A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...
Digital mobility metrics track Parkinson decline but offer no sample-size edge
A large observational study found that lower-back sensor measures of real-world walking declined over 24 months in Parkinson disease and ...
Oligodendroglial Alpha-Synuclein Rewires Midbrain Gene Programs Before Nigral Cell Loss in Mouse Model of MSA
In a mouse model of multiple system atrophy, oligodendroglial alpha-synuclein drives early ventral midbrain transcriptional changes in mitochondrial, metabolic and ...
Exon-Skipping Splicing Changes Distinguish Alzheimer’s Disease from Progressive Supranuclear Palsy
A genomic study of temporal cortex tissue identifies hundreds of exon-skipping events that separate Alzheimer's disease from progressive supranuclear palsy, ...
Retinal spectral imaging shows early Parkinson signals but no diagnostic signature yet
A scoping review finds only four in vivo studies of retinal spectral imaging and spectroscopy in Parkinson disease, with weak ...
How the STIM1 protein and store-operated calcium entry shape health and disease
A new review synthesizes how the calcium sensor STIM1 and store-operated calcium entry regulate physiology across tissues and contribute to ...
Tau PET Imaging Shows Faster Tau Buildup Tracks Faster Decline in PSP
A longitudinal PET study using the QST-developed tracer florzolotau found that patients with progressive supranuclear palsy whose brain tau accumulated ...
Progranulin Loss Impairs Cathepsin D Activity and Raises Insoluble TDP-43 in Mouse Brains
A mouse study finds that progranulin deficiency impairs cathepsin D enzymatic activity despite elevated protein levels, disrupts lysosomal organization, and ...
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