Tag: neurodegeneration

Diffusion-weighted MRI reveals altered white matter tissue fractions in patients along the dementia with Lewy bodies continuum compared to controls.

A new attention-based deep learning framework classifies Parkinson’s disease from resting-state EEG signals with high accuracy and provides interpretable sub-band ...

Regional brain ferritin accumulation tracks pathological TDP-43 signatures across aging, Alzheimer's disease, and amyotrophic lateral sclerosis.

A review in npj Parkinson's Disease examines the brain lymphatic drainage system's role in Parkinson's disease pathogenesis.

Proteomic analysis of aging macaques reveals region-specific molecular changes following chronic GCPII inhibition, highlighting potential therapeutic targets for sporadic Alzheimer's ...

PET imaging of 601 people showed that early-onset Alzheimer's disease involves more severe tau accumulation that rises faster across wider ...

A review highlights how exercise-responsive non-coding RNAs regulate key cellular processes and offer potential as non-invasive biomarkers across neurodegenerative diseases ...

Researchers using quantitative multiparametric magnetic resonance imaging detected widespread microstructural alterations across cortical and subcortical brain structures that track with ...

A review in Materials Today Bio details how precision nanoparticle systems can overcome the blood-brain barrier to target specific Alzheimer's ...

A study of 409 participants found that sleep-disordered breathing is associated with elevated cerebrospinal fluid markers of blood-brain barrier dysfunction ...

A study in Acta Neuropathologica Communications demonstrates that somatic TARDBP variants linked to FTLD-TDP-C disrupt morphology and increase microglia in ...

A narrative review in Genes and Environment finds that the APOE ε4 allele's risk for Alzheimer's disease is less pronounced ...

A study in EMBO Reports reports that mitochondrial APP and Aβ40 are associated with reduced CerS1/C18-ceramide accumulation and mitophagy readouts ...

A scientific review outlines how Rho-associated kinases govern mechanical signaling across ocular fibrosis, retinal injury, and central nervous system degeneration ...

A genetic variant in the KPNA3 promoter alters transcription factor binding and accelerates the clinical onset of spinocerebellar ataxia type ...

A preclinical study found that six weeks of candesartan administration did not modify tau pathology, receptor levels, or neuroinflammatory markers ...

A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...

A systematic review details how combining cerebrospinal fluid, blood, and saliva biomarkers establishes an accessible biological framework for diagnosing and ...

A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...

A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...