A Tablet App That Reads Facial Expressions Could Transform Parkinson’s Diagnosis
Researchers used a consumer tablet app to capture facial blendshape features that objectively quantify Parkinson's hypomimia, revealing asymmetry and interaction ...
Tag: neurodegeneration
The Golgi Apparatus Emerges as a Hidden Driver of Alzheimer’s Disease
A new review argues that the long-overlooked Golgi apparatus, supported by human genetic, proteomic, and lipidomic evidence, may be a ...
Two Separate Brain Gradients Reveal How Aging and Alzheimer’s Reshape Connectivity
A large two-cohort neuroimaging study shows that aging and Alzheimer's disease reorganize brain functional connectivity along two distinct cortical gradients, ...
TDP-43 Rides Multiple Molecular Motors Along Human Axons, Study Reveals
New research in human neurons shows that the ALS-linked RNA-binding protein TDP-43 is transported along axons by a flexible fleet ...
Antioxidant Protein Thioredoxin-1 Reshapes Oligodendrocyte Lineage Cells in Parkinson’s Model
A new study shows that the antioxidant protein thioredoxin-1 regulates the expansion of oligodendrocyte lineage cells and the accumulation of ...
Large Parkinson’s Study Confirms Rare ITSN1 Gene Variants Raise Disease Risk
An analysis of 8,660 genetically characterized Parkinson's patients from the ROPAD study confirms that heterozygous loss-of-function variants in the ITSN1 ...
How Well You Care for Your Brain Shows Up in Your Retina, Massive Study Finds
A UK Biobank study of nearly 29,000 adults links higher brain care scores to thicker retinal layers and a biologically ...
Dementia May Not Be a Brain Disease at All, NIH Scientists Argue
NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...
Scientists Map the Road to Better Stem Cell Brain Repair for Parkinson’s Disease
A new review in npj Parkinson's Disease examines the strategies needed to improve survival, differentiation and functional integration of stem ...
Synapse-Scanning PET Tracer Emerges as a Window Into Parkinson’s Disease Brain
A systematic review of seventeen studies finds that PET imaging of the synaptic vesicle glycoprotein 2A protein can reveal distinct ...
Sleep Changes in Parkinson’s Disease May Signal More Than Symptoms
A new letter in the Journal of Clinical Sleep Medicine argues that sleep changes in Parkinson's disease should be read ...
Protective APOE2 Gene Softens the Damage Wrought by Alzheimer’s Risk Gene APOE4
New research in mice shows that the protective APOE2 allele actively counteracts amyloid plaque buildup, microglial dysfunction, and proteomic changes ...
One in Three Parkinson’s Patients Faces Cognitive Decline, Landmark Analysis Finds
A meta-analysis of over 103,000 Parkinson's disease patients finds cognitive impairment affects roughly one in three, with orthostatic hypotension, diabetes, ...
Weight-Loss Surgery Linked to Sharply Lower Dementia and Parkinson’s Risk
A large matched cohort study of US health records finds that bariatric surgery is associated with substantially lower incidence of ...
When Alzheimer’s Isn’t Alzheimer’s: Prion Disease Hides in Rapid Dementia Cases
A new Mayo Clinic case series and systematic review shows that prion disease can convincingly mimic rapidly progressive Alzheimer disease, ...
ALS Progression Rate Before Diagnosis Fails to Predict Individual Disease Course, Landmark Study Finds
A population-based study of nearly 4,000 ALS patients in Italy shows that the widely used pre-diagnostic ALSFRS-R slope predicts group-level ...
Sleep Disorder and Memory Problems May Signal Parkinson’s Years Before Diagnosis
A large All of Us study finds that REM sleep behavior disorder, mild cognitive impairment, and orthostatic hypotension are the ...
Troubled Cholesterol Particle L5 Linked to Fading Language Networks in Early Cognitive Decline
A new GeroScience study finds that elevated levels of electronegative L5 cholesterol are associated with weakened connectivity in the brain's ...
MS Severity Gene Variant Also Tied to Slower Thinking in Healthy Adults, UK Biobank Study Finds
A genetic variant linked to faster multiple sclerosis progression is associated with subtly poorer reaction time, fluid intelligence and prospective ...
Cellular Antenna Turned Metabolic Command Center: How Primary Cilia Reshape Health and Disease
A new review redefines the primary cilium as a dynamic sensory-metabolic hub whose disruption contributes to cardiovascular, reproductive, metabolic, cancer ...
