Quercetin Plus Low-Dose Gamma Rays Curbed Chemically Induced Liver Cancer in Rats
In a rat model of chemically induced liver cancer, combining oral quercetin with fractionated low-dose gamma irradiation outperformed either treatment ...
Tag: autophagy
Kaempferol Eases Muscle Wasting in Mice With Cancer Cachexia
A study combining bibliometric mining, network pharmacology and mouse experiments identified the plant flavonoid kaempferol as a candidate compound against ...
Blocking Autophagy in Lung Macrophages Boosts Immune Priming Against Infections
Autophagy in alveolar macrophages restrains IL-1α production, and blocking it primes innate immunity that speeds clearance of bacterial and viral ...
Rabies virus matrix protein stabilizes RGS4 to curb ferroptosis and aid replication
Rabies virus matrix protein stabilizes RGS4 through incomplete autophagy, suppressing neuronal ferroptosis and supporting viral replication.
Collagen-Coated Rapamycin Liposomes Show Cartilage Repair Promise in Rats
A collagen-coated rapamycin liposome system preserved cartilage structure and showed no organ toxicity in a rat model of osteoarthritis.
How Natural Products Target Gut Microbes and Multiomics Signals in Diabetic Kidney Disease
A new review maps how natural products and traditional Chinese medicines may ease diabetic kidney disease by reshaping gut microbiota, ...
After Critical Illness, Muscle Retains Its Response to Exercise and Protein
A tracer study of ICU survivors found that muscle protein synthesis after maximal resistance exercise and whey protein reached the ...
Journal Retracts 2018 Valproic Acid Brain Injury Study Over Image Integrity Concerns
Frontiers in Molecular Neuroscience has retracted a 2018 study on valproic acid and traumatic brain injury after an investigation found ...
Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
Plumbagin-loaded thermoresponsive nanoparticles show anticancer effects in cervical cancer cells
A chitosan–PLA nanoformulation released plumbagin in a temperature-dependent manner and triggered apoptosis, autophagy and G2/M arrest in LPS-induced SiHa cervical ...
Hydroxychloroquine Fails to Boost Chemotherapy Response in Pooled Cancer Trial Analysis
A systematic review and meta-analysis of seven studies in 383 patients found that adding hydroxychloroquine to standard chemotherapy did not ...
Aging Reshapes How Lung Stem Cells and Their Niche Talk to Each Other
A mouse study finds aged lung progenitor cells retain organoid-forming capacity through heightened autophagy, while senescent Zmpste24-deficient fibroblasts with mTORC1 ...
Macrophages Take Center Stage in the Battle Against Sepsis
A new review argues that macrophages, through their polarization, metabolic reprogramming and autophagy, hold the key to understanding sepsis and ...
CRISPR Screen Reveals How Ovarian Cancer Cells Resist Niraparib
A genome-wide CRISPR screen identifies UGCG-driven sphingolipid metabolism and protective autophagy as drivers of Niraparib resistance in ovarian cancer.
Blue light disrupts DNA repair in skin cells through an ITGB3–PI3K/AKT pathway, study finds
A new study reports that blue light triggers autophagy imbalance and defective DNA damage repair in keratinocytes by raising ROS, ...
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
AP2A1 emerges as a possible switch between senescence and rejuvenation in human cells
A new review in Discover Aging examines how the AP2A1 protein, long known for its role in clathrin-mediated endocytosis, has ...
Varenicline’s molecular mechanisms in neuropsychiatric disorders reviewed
A new review examines how the α4β2 nicotinic receptor agonist varenicline might act on molecular pathways involved in neuropsychiatric disorders.
Lck kinase fine-tunes T cell activation by phosphorylating autophagy receptor p62
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
Research report: NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN ...
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