Tag: autophagy

A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...

A rat study published in Biological Research reports that Dingkun Pill reduced oxidative stress, follicular depletion, and cell death in ...

Complete deletion of the ALS-linked gene TBK1 suppresses microglial activation and extends disease duration in SOD1-ALS model mice, a new ...

Frontiers in Oncology has retracted a 2025 corrigendum on the anticancer effects of ABTL0812 in glioblastoma models after the authors ...

A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...

A pH- and ROS-responsive hydrogel carrying CRISPR-Cas9 silenced the TRPV4 calcium channel in rat discs, restoring autophagic flux and slowing ...

New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing ...

Chronic intracerebroventricular neuropeptide S treatment increased NREM sleep and reduced amyloid-related pathology in APP/PS1 Alzheimer's model mice, with BV2 cell ...

A case report describes two Chinese women with severe Danon disease initially suspected of cardiac amyloidosis, diagnosed through biopsy and ...

A machine-learning pipeline identified AML-selective small molecules and implicated glutathione reductase as a vulnerability that can be exploited in laboratory ...

A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across several neurological disorders.

A preclinical study reports that cannabidiol selectively impaired viability, migration, invasion, and clonogenic survival of cisplatin-resistant HPV-negative head and neck ...

A review of preclinical evidence finds that lipid-storage, fatty-acid oxidation, phospholipid and antioxidant programs can influence multiple processes linked to ...

New research in Aspergillus oryzae shows that vacuolar proteases govern autophagic body breakdown and nuclear degradation in ways that defy ...

Calycosin reduced myocardial injury in diabetic mice in association with increased Rab7a-dependent lipophagy, while Rab7a silencing removed its protective effects ...

A review of 86 cellular, animal and clinical studies reports multiple antitumor mechanisms for ginsenosides in liver-cancer models, while noting ...

Deep inside the brain, a tiny antenna on each neuron may determine how gracefully the body ages. A new study ...

A preclinical mouse study found that Gudan Wan reduced liver injury, inflammation and fibrosis while altering autophagy- and apoptosis-related proteins, ...

Cross-sectional human profiling and laboratory experiments indicate that Bacteroides fragilis outer membrane vesicles can trigger autophagy and reduce Pseudomonadota colonization ...

A review describes how RXLR effectors from the potato late blight pathogen target multiple immune and cellular processes that support ...