Tag: autophagy

Experiments in amoebae and murine microglial cells show that EsxA initiates repairable vacuole membrane lesions, while PDIM helps those lesions ...

A laboratory study found that L-carnitine attenuated selected signaling, biochemical and viability changes induced by trastuzumab in cardiac H9c2 cells.

A 2026 review identifies shared pathways involving synapses, immunity, metabolism, epigenetics and waste clearance in autism and Alzheimer’s disease, while ...

A narrative review concludes that fungal autophagy coordinates membrane biogenesis, organelle turnover, stress signaling, development and host interactions, although direct ...

Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.

A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors ...

A review identifies lysosomal pH dysregulation as a plausible context-dependent amplifier of sepsis-associated lung injury, but finds that most supporting ...

Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...

A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...

A new review reveals how lysosome–autophagy networks orchestrate lung maturation and may reshape treatment of bronchopulmonary dysplasia, cystic fibrosis, and ...

A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...

A new review details how the cellular recycling pathway autophagy coordinates every stage of skin wound healing and how drugs, ...

Every year, millions of people survive heart attacks because modern medicine can reopen blocked coronary arteries with remarkable speed. Yet ...

New research shows that remote ischaemic preconditioning protects kidneys from reperfusion injury by activating SIRT3-dependent, Parkin-mediated mitophagy in renal tubular ...

A rigorous new review finds that the BAG3-HSP70 autophagy axis is prognostically relevant and pharmacologically tractable in acute myeloid leukemia, ...

A cell-permeable peptide that activates autophagy improved grip strength, endurance, and balance in aged mice and produced gains comparable to ...

A ginseng compound slowed neuronal aging in Caenorhabditis elegans through phosphoinositide signaling, TOR suppression, and HLH-30/TFEB activation, offering a new ...

A sweeping review reveals how the chemotherapy drug doxorubicin breaks the heart's mitochondrial and ER recycling systems at multiple checkpoints, ...

A new review finds that ginseng-derived ginsenosides show context-dependent effects on healthy and malignant blood cells in laboratory models, but ...

New research in Aging Cell shows that sleeve gastrectomy reduced amyloid plaques, neuroinflammation, and diet-exacerbated memory deficits in Alzheimer's model ...