Stomach Surgery Slows Alzheimer’s Disease in Mice, Study Finds
New research in Aging Cell shows that sleeve gastrectomy reduced amyloid plaques, neuroinflammation, and diet-exacerbated memory deficits in Alzheimer's model ...
Tag: autophagy
From Glycans to Mitochondria: Women Scientists Map the Frontiers of Cell Death Research
A new Frontiers in Cell Death Research Topic curated by women scientists collects five studies spanning necroptosis, death receptor glycans, ...
Tiny RNA Molecule Reveals How Nerves Fight Back Against Chemotherapy Damage
Researchers in South Korea have shown that the microRNA miR-378f directly targets CAB39 to regulate AMPK/mTOR signaling and autophagy, revealing ...
Cellular Bubbles and Molecular Trash Tags: A New Route for Antibody Drugs Into the Brain
University of Ottawa researchers report that extracellular vesicles can ferry engineered antibodies across the blood-brain barrier, and that tagging disease ...
Curcumin Shows Multi-Pathway Effects in Cellular Models of Huntington’s Disease
New research shows that curcumin reduces mutant huntingtin aggregation, restores mitochondrial function, lowers oxidative stress, modulates epigenetic marks and suppresses ...
Inside the Nucleus: How a Fly Protein Guards Aging Neurons Against Death
A new review highlights how the nuclear scaffold protein LaminB acts as a stress-integration gatekeeper in neurons, with Drosophila studies ...
Grape Seed Compound Shows Promise Against Gluten-Induced Gut Cell Stress
A grape seed-derived polyphenol may protect the intestinal lining from a notorious gluten peptide, according to new research published in ...
Chlorogenic Acid Shields Aging Gut Stem Cells Through the Fly Version of NRF2
A new GeroScience study shows that the dietary polyphenol chlorogenic acid protects aging intestinal stem cells from oxidative stress in ...
Giant Protein Titin Found to Steer Uterine Contractions and Embryo Implantation
A new mouse study reveals that the giant muscle protein titin acts as a mechanosensory hub in uterine smooth muscle, ...
RNA-Binding Protein HuR Emerges as a Master Switch in Tau Splicing and Alzheimer’s Genes
A new study identifies the RNA-binding protein HuR as a repressor of tau exon 10 splicing and a regulator of ...
Trehalose, the Gut Microbiome, and a New Lead in Multiple Sclerosis Research
A new review suggests that the natural sugar trehalose may influence multiple sclerosis by inducing autophagy, reducing inflammation, and reshaping ...
How Pancreatic Cancer Cells Survive Detachment: Autophagy Emerges as Key to Spread
Researchers at Lund University have shown that pancreatic cancer cells engineered to survive detachment consistently switch on autophagy and ubiquitin ...
Two Genes Team Up to Paint Barley Leaves in White and Green
German researchers have shown that white-striped leaves in an EMS-mutagenized barley line arise only when recessive mutations at two epistatic ...
Ancient Growth-Control Pathway Emerges as a Master Switch of Brain Ageing
A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...
Ginseng Fights Fatigue by Switching Off Runaway Autophagy in Muscle Cells
A new mouse study shows that Panax ginseng relieves fatigue by reactivating the PI3K/AKT/mTOR pathway to suppress excessive autophagy and ...
Scientists Uncover Hidden Protein Driver Behind Scarring Kidney Disease
New research reveals that the protein Annexin A1 drives kidney fibrosis by activating YAP signaling and suppressing autophagy in renal ...
Bats and Whales Age Differently: Genomes Reveal Two Separate Roads to Long Life
A new comparative genomic study finds that small long-lived mammals like bats rely on DNA repair and autophagy while large ...
Damaged Mitochondrial DNA Emerges as a Central Driver of Pulmonary Arterial Hypertension
A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...
Hidden RNA switches that control the cellular recycling behind bone loss
A new review maps how microRNAs, long non-coding RNAs and circular RNAs tune autophagy in bone cells, opening a fresh ...
Circular RNA Culprit Behind Imatinib Failure in Leukemia Identified
Researchers in China have identified a circular RNA, hsa_circ_0029325, that drives imatinib resistance in chronic myeloid leukemia by upregulating the ...
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Deep Learning Model Accelerates Drug Target Screening and Repurposing Opportunities