Smurf1 Knockdown Drives Liver Failure via Ferroptosis
A new study reveals that knocking down the protein Smurf1 promotes ferroptosis in acute liver failure by stabilizing Ulk1 and ...
Tag: autophagy
Antifungal Drug Butoconazole Suppresses Liver Cancer by Disrupting Cellular Energy Metabolism
Researchers have identified the antifungal drug butoconazole as a dual inhibitor of energy metabolism that suppresses liver cancer growth in ...
Prenatal Nutrition Dominates Autophagic Programming in Growth-Restricted Rat Offspring
A rat study reveals that fetal growth restriction programs long-term autophagic dysfunction independently of post-weaning high-fat diet exposure.
Glycolate Oxidase Enhances Autophagy Defense Against Citrus Leaf Blotch Virus
Researchers found that glycolate oxidase promotes hydrogen peroxide accumulation and autophagy to restrict citrus leaf blotch virus infection in plants.
Impaired Autophagy Axis Drives Decidual Cell Aging and Spontaneous Abortion
A study reveals that impaired autophagy driven by elevated branched-chain amino acids accelerates decidual stromal cell senescence and triggers spontaneous ...
Chemotherapy triggers a TNF autophagy loop that helps tumours resist treatment
Chemotherapy activates cGAS–STING in head and neck cancer cells, driving TNF release, IKKβ-mediated ATG9A S654 phosphorylation and autophagy that promotes ...
Transcriptomic Analysis Examines Autophagy Signatures in Tuberculosis and Diabetes Comorbidity
An exploratory multi-dataset transcriptomic analysis identified host autophagy-related gene signatures in tuberculosis-diabetes comorbidity, finding that the observed transcriptional alterations are ...
Liensinine targets ATG9B to curb autophagy dysfunction in PCOS models
Researchers found that the natural compound liensinine binds ATG9B to modulate AKT/mTOR signalling and reduce excessive autophagy in PCOS cell ...
Plant Polyphenols May Steer Muscle Protein Deposition Through mTOR and AMPK
A new review maps how plant polyphenols such as quercetin, curcumin, and resveratrol may regulate muscle protein synthesis and degradation ...
Review Identifies ATG5 as Context-Dependent Switch in Cancer Drug Resistance
A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...
MicroRNA Blocks Stomach Cancer Growth by Silencing AHR and Triggering Autophagy
A new study reports that microRNA-124-3p directly targets the AHR gene to activate autophagy, suppressing stomach adenocarcinoma cell growth in ...
LncRNA AK158273 curbs microglial autophagy via Mst1 in LPS neuroinflammation model
A new study reports that lncR-AK158273 suppresses microglial autophagy during LPS-induced neuroinflammation by upregulating Mst1 expression.
TBK1 clears aggregation-prone TDP-43 via an IFNβ-immunoproteasome pathway in ALS models
Researchers report that the ALS-linked kinase TBK1 clears aggregation-prone monomeric TDP-43 in neurons by inducing interferon-β and the immunoproteasome, an ...
CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
New ATG4-targeting peptide blocks autophagy and kills cancer cells in mice
A newly designed cell-penetrating peptide that inhibits the autophagy enzyme ATG4 raised reactive oxygen species and significantly reduced tumor size ...
Alcohol Kills Esophageal Cells Mostly Through Ferroptosis, Lab Study Finds
An in vitro study of human esophageal epithelial cell lines found that brief alcohol exposure promoted autophagy-driven growth while longer ...
CaMKII Emerges as Central Molecular Hub Driving the Ageing Heart
A new review synthesizes preclinical evidence that the CaMKIIδ kinase integrates calcium dysregulation, inflammation, autophagy failure, mitochondrial decline and DNA ...
NF-κB/Atg5 Axis Linked to Treg Dysfunction in Kidney Antibody-Mediated Rejection
A new study identifies Atg5-dependent Treg regulation as a mechanistic link between Treg dysfunction and macrophage inflammation in kidney antibody-mediated ...
SAT1 Overexpression Eases Alpha-Synuclein Toxicity in Fly Model of Parkinson’s Disease
In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response ...
Cellular Stress Protein JWA Emerges as Context-Dependent Redox Hub in Aging and Disease
A new narrative review synthesizes how the multifunctional protein JWA intersects with redox homeostasis across cancer, neurodegeneration and tissue injury, ...
