RBBP5 Emerges as a Master Epigenetic Switch Controlling the Cell’s 12-Hour Proteostasis Clock
A new PLOS Biology study identifies the COMPASS complex subunit RBBP5 as the central epigenetic regulator of the cell's 12-hour ...
Tag: autophagy
Machine Learning Maps How Environment and Immunity Shape Childhood Eczema Risk
A machine learning analysis of 217 South African AmaXhosa children has identified one protective and two susceptibility clusters linking rural ...
ZBED6 Loss Fuels Pathological Heart Enlargement Through a Newly Mapped Gene Switch
New research in PLOS Genetics identifies the ZBED6–MEOX1–ERK1/2 axis as a key regulator of pathological cardiac hypertrophy through impaired autophagy.
Single GTPase Governs a Strange Autophagy-Like Pathway in the Parasite Giardia
Researchers have discovered that Giardia lamblia runs an ATG8-independent autophagy-like pathway regulated by its sole Rho GTPase, GlRac, revealing a ...
How Pathogens Hijack Mitophagy and What It Means for Treating Infection
A new review details how bacteria and viruses hijack or block the mitochondrial quality-control pathway of mitophagy to survive, evade ...
Bacterial Toxin Hijacks Mitochondria to Trigger Fatal Cell Death in Bovine Mastitis
New research reveals that the Staphylococcus aureus virulence factor Sph disrupts mitochondrial cristae through Mic60, releasing mtDNA that activates the ...
Diabetes Drugs May Ease Pulmonary Hypertension by Taming Activin A Signaling
A new study links SGLT2 inhibitor therapy with reduced circulating activin A, improved right-heart function, and modulation of BMP/activin signaling ...
Blocking a Single Protein Makes Childhood Cancer Cells Easier for Immunotherapy to Find
Penn State researchers found that blocking the protein VPS34 raises levels of the GD2 molecule on neuroblastoma cells, making them ...
Hidden Protein Networks Emerge as Central Players in Huntington’s Disease
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
Cellular Recycling Machine Linked to Male Fertility Hormone Control
New research reveals that the cellular recycling protein p97/VCP directly regulates the autophagic degradation of androgen-binding protein in Sertoli cells, ...
Bladder Cancer Breakthrough: BH3 Mimetics Make Cisplatin Deadly Again
New research shows that BH3 mimetic drugs targeting antiapoptotic Bcl-2 family proteins can sensitize bladder cancer cells and patient-derived tumor ...
Brief Vaping Exposure Leaves Lasting Damage in the Lung’s Deepest Tissue, Study Finds
A new study in JCI Insight shows that just days of e-cigarette vapor exposure damages the human distal lung, with ...
Calpain Blocker Restores Cellular Cleanup Crew and Protects Blood Vessels in Diabetes
A new study shows that overactivated calpains block autophagy and mitophagy in endothelial cells under high glucose, and that inhibiting ...
Cellular Freight Protein YKT6 Emerges as a Driver of Lung Cancer Growth
A new study finds that the vesicle-trafficking SNARE protein YKT6 is overexpressed in lung cancer, where it drives proliferation and ...
Plateau Fish Rewire Their Immune Systems to Survive Oxygen Starvation
A new genomic study reveals that the Tibetan plateau fish Gymnocypris eckloni deploys distinct immune strategies against severe short-term and ...
Scientists Map the Iron Recycling Switch That Decides Whether Cells Live or Die
A new review in the Journal of Translational Medicine maps how NCOA4-mediated ferritinophagy controls iron release and ferroptosis, cataloguing small-molecule ...
Rotten-Egg Gas Arms Wheat Against Rust by Switching On Cellular Recycling
New research shows that hydrogen sulfide enhances wheat resistance to stripe rust by persulfidating the autophagy protein TaATG6c, thereby activating ...
Scientists Find Druggable Switch That Controls the Cell’s Master Recycling Regulator TFEB
A Nature study from TIGEM reveals a previously unknown TBK1-ULK1 signaling pathway that controls the master recycling regulator TFEB, exposing ...
Venetoclax Enhances Apoptosis and Autophagy in APL
In the evolving landscape of cancer treatment, the persistent challenge of drug resistance remains a significant obstacle, particularly in the ...
ALDH2’s Role in Autophagy and Cell Death
In recent studies, the enzyme aldehyde dehydrogenase 2, commonly known as ALDH2, has emerged as a critical player in the ...
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