Witnessing Defeat Is Not the Same as Suffering It: Mouse Study Shows Two Stress Models Diverge
A controlled mouse study finds that witnessed social defeat produces overlapping but distinct behavioral and hippocampal molecular effects from direct ...
Tag: Hippocampus
Parvalbumin Protein Loss Linked to Epilepsy-Related Cognitive Impairment in Mice
A mouse study finds that restoring parvalbumin signaling in the hippocampus rescues epilepsy-related cognitive impairment by regulating CaMKIIα autophosphorylation and ...
Blue Light Plus Exercise Restores Memory and Brain Rhythms in Alzheimer’s Mice
A one-week combination of ipRGC-sensitive blue light and exercise rescued memory deficits and restored pathological hippocampal rhythms in Alzheimer's model ...
Electroacupuncture Eases Cognitive Impairment in Schizophrenia Model Mice
A preclinical mouse study reports that electroacupuncture at the ST36 acupoint improved recognition memory over three weeks while suppressing neuroinflammation ...
Research report: Hericium erinaceus polysaccharide ameliorates spatial working memory impairment and intestinal barrier dysfunction in high-fat high-sucrose diet-fed mic
A lion's mane mushroom polysaccharide partially reversed metabolic, intestinal barrier, and spatial memory deficits in mice fed a high-fat, high-sucrose ...
Brain Glutamate Networks Differ in First-Episode Psychosis, Seven-Tesla Study Finds
A seven-tesla imaging study found no regional glutamate differences in antipsychotic-free first-episode psychosis, but patients showed widespread inter-regional glutamate correlations ...
Dragon’s Blood Resin Shows Preclinical Promise for Protecting Post-Stroke Memory
A new review finds that Dragon's Blood resin and its active components show multi-target protective effects against ischemia-induced memory impairment ...
LINAC-Based Radiosurgery Cuts Seizures in Drug-Resistant Temporal Lobe Epilepsy
A small Mexican case series found that non-invasive LINAC-based radiosurgery reduced seizure frequency by 75.6 percent in drug-resistant mesial temporal ...
Astrocyte Subtype Marked by CD51 Drives Synapse Formation and Stroke Recovery in Mice
A new mouse tool reveals that CD51-positive astrocytes are a functionally distinct subpopulation that promotes cortical synapse formation, hippocampal circuit ...
Amygdala neurons that fire early decide which images become lasting memories
Direct recordings in neurosurgical patients show that category-selective amygdala neurons fire earlier and more strongly for images people later remember, ...
Hippocampus encodes experience as disentangled variables in cell assemblies
A study in behaving mice reports that the hippocampus encodes different aspects of experience as disentangled variables in cell assemblies, ...
Research report: In vivo blood and ex vivo brain solid-phase microextraction coupled with LC-MS/MS for mapping unbound cannabidiol, phase I metabolites, and endocannabinoid tone
A solid-phase microextraction and LC-MS/MS platform has, for the first time, tracked unbound cannabidiol in the living bloodstream and mapped ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
CD51 defines specialized astrocyte roles in mouse brain circuits
A mouse study shows that CD51-positive and CD51-negative astrocytes have distinct roles in synapse formation, memory-circuit adaptation and recovery from ...
Unstable Regulatory T Cells Weaken the Blood–Brain Barrier After Surgery
A study in Cell Death Discovery links perioperative destabilization of regulatory T cells to blood–brain barrier disruption through a β-catenin–tight ...
Vitamin D Emerges as Possible Bridge Between Neuropathic Pain and Brain Fog
A new narrative review maps how vitamin D deficiency may sit at the mechanistic crossroads of neuropathic pain and cognitive ...
Loneliness linked to smaller brain memory regions when Alzheimer’s biomarker is elevated
A large IGNITE study of cognitively unimpaired older adults found that loneliness was associated with smaller CA3 and entorhinal cortex ...
SIK1–NR4A2 pathway linked to excitability in rat epilepsy model
Machine-learning screening and experiments in rats and cultured neurons identified SIK1 as a regulator of seizure severity and neuronal excitability ...
Angelman syndrome mice show disrupted Kv4.2 channel redistribution
A mouse study links loss of UBE3A to impaired Kv4.2–DPP6 complex remodeling and weakened dendritic channel gradients associated with excitability ...
Immature brain support cells linked to poorer reasoning in older adults
A USC-led study of 29 adults with epilepsy found that more abnormal immature astroglia in the hippocampus were associated with ...
