Rat study finds exercise-dependent BDNF and cognitive responses
An eight-week study of 40 male Wistar rats found that hippocampal BDNF responses and cognitive performance varied across endurance, rotarod, ...
Tag: Hippocampus
Modified Dioscorea Pills improve cognition in rat cerebral hypoperfusion model
A 14-herb Chinese medicine improved learning and memory and altered hippocampal injury and vascular markers in rats with experimentally induced ...
Immature Astroglia Track Fluid-Intelligence Decline in Epilepsy Patients
An observational study of people with mesial temporal lobe epilepsy found that more pathological immature astroglia in the hippocampus was ...
Coreopsis Polyphenols Reverse Stress-Related Depression Signals in Mice
A Coreopsis tinctoria polyphenol extract reduced stress-related behavioral deficits and restored serotonin, antioxidant, hormonal, inflammatory and hippocampal signals in CUMS-exposed ...
Walking Patterns Reveal Alzheimer’s Risk Differently in Women and Men, Study Finds
A new study of 253 older adults finds that amyloid pathology alters gait and hippocampal structure in sex-specific ways during ...
Rat Study Reveals the Thalamic Nucleus Reuniens as an Active Hub in Spatial Learning
New recordings in navigating rats show that spatial learning selectively strengthens information flow from the hippocampus into the thalamic nucleus ...
How to train your neuron: building a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells
Researchers have built and validated a new general-purpose biophysical model of hippocampal CA1 pyramidal neurons that captures a wide range ...
Traditional Japanese Herbal Medicine Eases Anxiety in Premenstrual Syndrome Rat Model by Reshaping Brain GABA Receptors
A traditional Japanese Kampo medicine reduced anxiety-like behavior in a rat model of premenstrual syndrome by reversing withdrawal-induced increases in ...
Hippocampal GluN2A Knockdown Differentially Alters Spatial Exploration and Behavioral Performance in Male and Female Rats
A new study shows that selectively reducing the GluN2A subunit of NMDA receptors in the adult hippocampus disrupts spatial exploration ...
Chronic Stress Rewires the Brain in Stages, Longitudinal fMRI Study of Mice Reveals
A longitudinal fMRI study in mice shows that chronic stress dismantles brain function in stages, from local hub breakdown to ...
Gut Inflammation, Anxious Brain: Dexpanthenol Eases Colitis-Linked Anxiety in Rats
The relationship between intestinal inflammation and behavioral changes has become one of the more compelling frontiers in gastroenterology and neuroscience ...
Synthetic Macamide Analog Reshapes Hippocampal Endocannabinoid System but Fails to Prevent Seizure Progression in Rats
A new FAAH-inhibiting macamide analog, MCH-02, induced significant molecular remodeling of the hippocampal endocannabinoid system and BK channel expression in ...
One Synapse, Many Memories: How the Brain Builds LTP in Different Ways
New evidence shows the hippocampus expresses multiple mechanistically distinct forms of long-term potentiation, shaped by sex, brain region, and induction ...
Your Pupils May Reveal How the Brain Decides What to Remember, New Framework Suggests
A new theoretical framework proposes that pupil dynamics measured non-invasively can serve as a systems-level biomarker linking dopamine and norepinephrine ...
Shared Molecular Fingerprint of Alzheimer’s and Lewy Body Dementia Revealed in Human Brain Maps
A whole-transcriptome study of five brain regions from verified Alzheimer's and Lewy body dementia donors reveals a shared molecular signature ...
Memory as a Selection Process: New Framework Rethinks How Experiences Become Lasting Knowledge
The distinction drawn between selective stabilization and relational integration invites comparison with long-standing debates in memory science about why some ...
Desert Plant Compound Restores Sleep-Deprived Brains by Switching On a Key Antioxidant Pathway
A new rat study shows that glycosides from the desert plant Cistanche reverse sleep deprivation-induced cognitive decline by activating the ...
Prior Flu Infection Reshapes Brain Inflammation and Behavior in Alzheimer’s Mice
A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...
Stroke Reshapes Gut Microbes and Brain Chemistry in Rats, Multi-Omics Study Finds
A multi-omics study in rats reveals that permanent middle cerebral artery occlusion remodels cecal microbiota and drives a lipid-centered inflammatory ...
Baby Rats Remember Differently: Hidden Exploratory Strategies Reveal What Standard Memory Tests Miss
A new perspective argues that standard novelty-preference scores in rodent recognition memory tests conceal developmental differences, with pre-weanling rats switching ...
