Ezetimibe and Sericin Combination Reduces Cadmium Neurotoxicity in Rat Study
A combination of ezetimibe and sericin alleviated cadmium chloride-induced neurotoxicity, oxidative stress, and neuroinflammation in an experimental rat model.
Tag: Hippocampus
Selegiline shields mouse memory from repeated anesthesia damage
Repeated isoflurane exposure impaired memory and hippocampal CA1 function in mice, and pretreatment with the approved drug selegiline prevented most ...
Astrocyte Glutamate Uptake Shapes Fear Memory Expression and Reconsolidation in Male Rats
Blocking the astrocytic glutamate transporter GLT-1 in the rat hippocampus spares fear memory formation but disrupts its expression and reconsolidation ...
Stress in childhood linked to later binge eating, but brain networks may not explain why
Greater exposure to negative life events at age nine or ten predicted more binge eating symptoms two years later in ...
DNAH14 Gene Loss Drives Ependymal Cilia Dysfunction and Hydrocephalus in Mice
A study in mice demonstrates that DNAH14 knockout impairs ependymal ciliary motility, leading to chronic hydrocephalus, behavioral deficits, and hippocampal ...
Astrocytic Cilia Receptor Drives Amyloid Beta Accumulation and Brain Cell Stress
Researchers have discovered that the ciliary p75 neurotrophin receptor mediates amyloid beta accumulation and oxidative stress in human hippocampal astrocytes.
Chronic formaldehyde inhalation damages key interneurons in rat brain study
A 28-day formaldehyde inhalation study in male Wistar rats found widespread loss of parvalbumin interneurons, glial activation and behavioural deficits ...
RACK1 Loss Drives Neuronal Necroptosis in Mouse Sepsis Brain Study
A new Cell & Bioscience study in mice shows that downregulated hippocampal RACK1 potentiates LPS-induced neuronal necroptosis through the RACK1/RIPK1 ...
LncRNA AK158273 curbs microglial autophagy via Mst1 in LPS neuroinflammation model
A new study reports that lncR-AK158273 suppresses microglial autophagy during LPS-induced neuroinflammation by upregulating Mst1 expression.
Lactate Receptor HCAR1 Emerges as a Brain-Wide Tuner of Neuronal Firing
A new mini review details how the lactate receptor HCAR1 modulates neuronal firing across the brain through region-specific ion channel ...
Hippocampal Interneuron Subtypes Show Distinct Tonic Inhibition Plasticity
Brief NMDA receptor activation enhanced tonic GABAergic current density in a subset of non-OLM somatostatin-positive hippocampal interneurons while leaving OLM ...
Branched-Chain Amino Acid Supplements Partially Ease Hormone Disruption After Brain Injury in Rats
A rat study found that post-injury branched-chain amino acid supplementation partially restored thyroid hormones, vitamin D, calcium, and phosphorus levels ...
Silencing Gasdermin D Shields Hippocampal Neurons in Rat Status Epilepticus
In a lithium-pilocarpine rat model of status epilepticus, hippocampal GSDMD knockdown reduced pyroptosis and ferroptosis markers, improved neuronal survival, and ...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's ...
Vagus Nerve Stimulation Boosts Memory in Female Rats Only During Certain Estrous Phases
A single session of vagus nerve stimulation improved memory and hippocampal plasticity in female rats, but only when tested during ...
Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Blood Cholesterol Marker Flags Brain Injury Risk in Growth-Restricted Infants
A blood-based cholesterol metabolite, 24S-hydroxycholesterol, shows reduced levels in IUGR infants and predicts neurodevelopmental risk in new mouse and clinical ...
Loss of CD47 Shifts Mouse Hippocampus Toward a Mild Stress-Like State
Single-nucleus RNA sequencing shows that Cd47 loss shifts the mouse hippocampal transcriptome toward a state resembling mild excitotoxic stress.
Apigenin boosts norepinephrine release and brain lactate in aging-model mice
A new mouse and cell study found that the plant flavonoid apigenin improved chemically induced cognitive deficits by activating GPR30 ...
Rab5 Endosomal Overactivation Linked to Oxytocin Receptor Signalling Defects in Early Alzheimer’s Models
A study in young APP/PS1 mice and a Rab5-overactivation model links enlarged early endosomes to mislocalised oxytocin receptors, reduced ERK ...
