Chewing, Aging and Astrocytes: Mouse Study Links Diet Texture to Hippocampal Cells
A mouse study finds that age- and diet-dependent changes in astrocyte complexity within the hippocampal temporoammonic pathway parallel spatial learning ...
Tag: Hippocampus
Choroid Plexus Ablation Eases Hydrocephalus Brain Swelling in Mice
A viral gene therapy that ablates the cerebrospinal fluid-producing choroid plexus prevented hydrocephalus-related brain swelling in mice while moderately reducing ...
Caloric Restriction Beats Time-Restricted Feeding on Metabolism in Obese Rats, but TRF Shifts Behavior
In obese rats fed a high-sugar diet, caloric restriction produced stronger metabolic improvements than time-restricted feeding, which instead showed distinct ...
Emerging Neuroscientists Map Body, Brain and Behaviour Across the Lifespan
A new Frontiers Research Topic gathers studies led by early-career researchers in psychophysiology and cognitive neuroscience, spanning bodily self-representation, neural ...
REM Sleep Deprivation in Rats Tied to Manic- and OCD-Like Behaviors and Hippocampal Gene Changes
A rat study found that 14 days of REM sleep deprivation produced manic- and OCD-like behaviors in both sexes and ...
TBHQ Shows Protective Effects Against Cisplatin-Induced Neurotoxicity in Rats
A rat study found that the antioxidant compound TBHQ reduced cisplatin-induced cognitive deficits, oxidative stress and hippocampal inflammation.
Nandrolone Raises Calcineurin in Rat Hippocampus Alongside Memory Deficits
In male rats, chronic high-dose nandrolone decanoate impaired spatial and aversive memory while increasing calcineurin protein levels in both dorsal ...
Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
GPNMB–SMAD4 pathway links microglial inflammation to demyelination in diabetic cognitive dysfunction
A mouse and cell study finds that hyperglycemia lowers microglial GPNMB, disrupting its binding to SMAD4 and unleashing NF-κB-driven neuroinflammation ...
Exercise and testosterone help rat brains recover from morphine withdrawal
A rat study finds that treadmill exercise, especially at moderate intensity, partially restores memory and brain BDNF levels during morphine ...
Fetuin-A Reduction with Pioglitazone Eases Brain Inflammation in Aged Rats with Liver-Related Cognitive Impairment
In a rat study, lowering the protein Fetuin-A with pioglitazone was accompanied by reduced hippocampal neuroinflammation and recovered recognition memory ...
New microscopy method reaches 2-mm-deep neuronal imaging in the mouse brain
A new three-photon imaging system called TrUDI achieves cellular-resolution recordings of neuronal population activity at depths of up to about ...
Radiosurgery Eased Seizures in Drug-Resistant Epilepsy, but No Patient Became Seizure-Free
A seven-patient pilot study found that LINAC-based radiosurgery targeting the hippocampal head and anterior body cut median seizure frequency by ...
Aerobic exercise eases depressive-like behavior in stressed mice by calming hippocampal inflammation
In mice exposed to chronic mild stress, aerobic exercise reduced depressive-like behaviors and hippocampal neuroinflammation by inhibiting the HMGB1/NF-κB pathway ...
Magnesium Sulfate Shows Neuroprotective Effects in Mouse Model of Postoperative Cognitive Dysfunction
A new experimental study links magnesium sulfate's neuroprotective effects to AMPK/PINK1/Parkin signaling in postoperative cognitive dysfunction.
Acupuncture fMRI Findings Across the Alzheimer’s Continuum: What a Critical Review Reveals
A critical review of BOLD-fMRI studies finds acupuncture-related brain network changes across subjective cognitive decline, mild cognitive impairment, and Alzheimer's ...
Asymmetric Carotid Stenosis Model Shows Sharper Cognitive Decline in Mice
A mouse study found that an asymmetric 0.16/0.18-mm BCAS configuration produced earlier cognitive impairment, more persistent sensorimotor deficits, and more ...
Male mice hit harder by Parkinson’s-linked depression in new study
In an MPTP mouse model of Parkinson's disease, males developed stronger depressive- and anxiety-like behaviors alongside greater nigrostriatal degeneration, hippocampal ...
Dorsal and ventral hippocampus play distinct roles in memory span and supraspan performance in mice
A new mouse study shows that dorsal and intermediate-ventral hippocampus regions make distinct contributions to memory span and to performance ...
Witnessing Defeat Is Not the Same as Suffering It: Mouse Study Shows Two Stress Models Diverge
A controlled mouse study finds that witnessed social defeat produces overlapping but distinct behavioral and hippocampal molecular effects from direct ...
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