Two-pronged antibody depletes suppressive T cells and boosts antitumor immunity in mice
A new bispecific antibody targeting CCR8 and CD3 shrank breast, lung and colon tumors in mice and was well tolerated ...
Tag: tumor microenvironment
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
Cysteine Cathepsins Mapped Across Breast Tumors Reveal States That May Shape Antibody-Drug Conjugate Use
A single-cell and spatial atlas of 66 breast tumors shows cysteine cathepsins occupy specific immune, epithelial and stromal niches, and ...
Bibliometric Analysis Maps a Decade of MDSC Research in the Tumor Microenvironment
A bibliometric analysis of 5,967 publications maps a decade of MDSC research, identifying leading countries, institutions, authors, and emerging research ...
CAR-T Therapy for Brain Tumors Shows Early Promise and Persistent Barriers
A conference correspondence summarizing 12 clinical and translational abstracts on next-generation CAR-T therapy for malignant brain tumors, reporting early feasibility ...
Disease Microenvironments May Reshape the Safety of Near-Infrared Theranostic Nanomaterials, Review Finds
A new review argues that tumor acidity, hypoxia, reactive oxygen species and microbial cues can fundamentally alter the degradation, activation ...
Research report: POSTN+ tumor-associated endothelial cells promote and predict pulmonary metastasis in osteosarcoma
Researchers identified a POSTN-expressing tumor-associated endothelial cell subset that promotes and predicts pulmonary metastasis in osteosarcoma.
ROS-responsive nanoparticle pairs PARP inhibitor with DOT1L blocker to fire up antitumor immunity in ovarian cancer models
A ROS-responsive nanoparticle co-delivering a PARP inhibitor prodrug and a DOT1L inhibitor amplified DNA damage, activated cGAS-STING signaling and improved ...
Colorectal cancer peritoneal metastases often arise early and polyclonally, sequencing study finds
Sequencing of 11 colorectal cancer patients shows peritoneal metastases often arise early, polyclonally, and through metastasis-to-metastasis seeding.
Blocking a Nerve-Linked Ion Channel Turns Tumor Cell Stress Into Fatal Ferroptosis
A preclinical nanoplatform that blocks the TRPA1 ion channel while delivering glucose starvation, chemodynamic, and sonodynamic therapy suppressed tumor growth ...
Exosomes, mitochondrial vesicles and microRNA cargo emerge as a new chemopreventive frontier in cancer
A new review in Genes & Nutrition proposes that exosomes, mitochondria-derived vesicles and their microRNA cargo form a programmable signaling ...
B Cell Depletion Marks High-Risk Hodgkin Lymphoma, Spatial Study Finds
A spatial transcriptomics study links depletion of non-tumoral B cells to relapse risk in classical Hodgkin lymphoma and introduces an ...
AI pathology scoring flags longer survival on pembrolizumab in metastatic triple-negative breast cancer
An AI-based digital pathology assessment of PD-L1 identified metastatic triple-negative breast cancer patients with longer progression-free survival on pembrolizumab in ...
Extracellular vesicles emerge as dual players and tools in cancer immunotherapy
A new review describes how tumor-derived exosomes suppress immunity while immune-cell-derived vesicles boost antitumor responses, highlighting exosome-based vaccines and biomarkers.
AI Meets Bioprinting to Build Tumor Models for Drug Screening
A new review outlines how artificial intelligence is being combined with 3D bioprinting to build tumor models that mimic the ...
Stemness-Based Gene Signature Predicts Survival and Treatment Response in Liver Cancer
Researchers built a seven-gene tumor stemness signature from single-cell and bulk transcriptomic data that predicts survival, immunotherapy response, and oxaliplatin ...
Scientists engineer pH-sensitive liposomes that release drugs in acidic tumor environments
A multi-technique study shows DOPE-oleic acid liposomes with cRGD targeting stay stable at physiological pH and release cargo under acidic ...
Neutrophils Shift Metabolism in a Triple-Negative Breast Cancer Coculture Model
A lab coculture study found that adding neutrophils increased mitochondrial activity in a triple-negative breast cancer and fibroblast model.
Natural Compounds That Build Their Own Nanomedicines Take Aim at Cancer
A new review maps how natural active compounds can self-assemble into carrier-free nanostructures for cancer therapy, while flagging major translational ...
Bladder Cancer Gene Signature Holds Up Across Two Large Cohorts
A reanalysis of two independent bladder cancer cohorts found 4,102 genes with concordant tumor-associated expression changes and confirmed five candidates ...
POPULAR NEWS
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Research report: Beyond hemoglobin thresholds: identifying clinical predictors for red blood cell transfusion in pediatric severe anemia