Tag: tumor microenvironment

Scientists created a mouse colorectal cancer cell line carrying Kras, Apc and Trp53 mutations that forms aggressive rectal tumors resembling ...

A bioinformatics and single-cell study finds that S100P is elevated in lung adenocarcinoma, tracks with advanced stage and poorer survival, ...

A new review describes how prostate cancer reverses its specialized citrate-producing metabolism and how extracellular vesicles may transfer metabolic signals ...

A new study links VCAM-1 to colorectal cancer growth and spread through the RhoA/LIMK/Cofilin cytoskeletal pathway, while its survival association ...

A review describes how heat shock proteins influence tumor survival, metastasis, immune escape, and the design of future targeted cancer ...

A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.

A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...

A new mini-review outlines how epigenetic silencing of NK-activating ligands helps urothelial carcinoma evade immune attack and how DNMT and ...

A new open-access review maps how stem cell-derived extracellular vesicles could serve as dual therapeutic and diagnostic tools in precision ...

A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...

A new Frontiers in Oncology Research Topic gathers six articles examining how metabolism, inflammation, immunity and the gut microbiome influence ...

Endothelial ICAM-1 becomes polarized to the tumor periphery as melanomas grow, trapping T cells at the margins, and blocking it ...

A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.

A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in ...

Researchers have developed a protocol that keeps mouse bone and marrow alive in a dish for up to four weeks ...

A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...

A preclinical study reports that the MEK inhibitor cobimetinib suppressed MAPK signaling, tumor cell invasion and immune-evasive features in anaplastic ...

A study of breast tissue microarrays mapped where regulatory RNAs and stromal proteins sit within benign, DCIS and invasive lesions, ...

A new review explains how regulatory T cells are co-opted by ovarian tumors to suppress immunity, and how precision therapies ...

A computational analysis of single-cell RNA sequencing data maps 208 prognosis-linked miRNA-target pairs carried by extracellular vesicles in the hepatocellular ...