Tag: tumor microenvironment

A new review examines how peptide-functionalized hydrogels and scaffolds could support CAR-NK cell therapy in solid tumors, while noting that ...

A new study identifies an eight-gene signature linked to vitamin metabolism that effectively stratifies risk in uterine corpus endometrial carcinoma ...

A mechanistic review evaluates how stereotactic body radiotherapy reshapes the pancreatic ductal adenocarcinoma microenvironment by simultaneously triggering localized immune activation ...

A computational model based on thirteen succinylation-related genes stratifies breast cancer survival outcomes and correlates with immune infiltration, mutation patterns, ...

An integrative hypothesis-generating analysis identified SPP1 and extracellular matrix remodeling as candidate features linking bisphenol A exposure to an immunosuppressive ...

A comprehensive multi-cohort study reveals elevated COL1A2 expression in gastric cancer, detailing its modest prognostic contribution, stromal associations, and computational ...

Spatial profiling of melanoma tumors reveals that lipid-associated macrophage neighborhoods drive immune exclusion and predict resistance to checkpoint inhibitor therapy.

Researchers developed a multiplexed immunoassay that measures immune checkpoint proteins on the surface of plasma extracellular vesicles and found generally ...

Pharmaceutical STING activation reduced primary tumor recurrence and extended survival in a mouse model of metastatic triple negative breast cancer.

A multi-cohort retrospective investigation and laboratory analysis revealed that downregulation of the lipid metabolism gene AGPAT4 in thyroid cancer distinguishes ...

A study integrating spatial transcriptomics, single-cell RNA sequencing and a 27-patient clinical cohort links peritumoral tertiary lymphoid structures and high ...

Single-cell and spatial transcriptomics of mouse skin tumors reveal that myeloid-derived oncostatin M and TGFβ1 establish distinct stromal niches that ...

Overexpression of FAM136A independently predicts poorer survival outcomes in skin cutaneous melanoma while correlating with immune cell infiltration and PDCD1 ...

A transcriptomic profiling study identified ARSB as a candidate tumor suppressor that constrains colorectal cancer progression by coordinating ERK signaling ...

A comprehensive review outlines how aging and tumor signaling remodel circulating platelets into hyperreactive, immunosuppressive cellular fragments that drive thromboinflammation ...

A new review maps how the m7G RNA modification acts across distinct RNA compartments to drive codon-biased translation, tumor adaptation, ...

A review highlights how m6A RNA regulation connects ferroptosis and immune remodeling in non-small cell lung cancer, noting that direct ...

Endosialin-positive fibroblasts and pericytes drive colorectal cancer angiogenesis through NF-κB and HIF-1α signaling that boosts VEGFA secretion, and an anti-endosialin ...

Researchers developed PL051, a syngeneic mouse prostate cancer cell line that is androgen-dependent, metastatic and immunocompetent, enabling tests of combined ...

A narrative review argues that MEK inhibitors have transformed treatment of NF1-associated plexiform neurofibromas, but predominantly partial responses, toxicity, and ...