Tag: tumor microenvironment

A new review synthesizes how tissue-resident memory T cells act as frontline immune sentinels in tumors and could guide biomarker ...

A longitudinal single-cell study of ER-positive breast cancer links strong estrogen receptor signaling, ER-linked enhancer activity and expanding T cell ...

Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...

A single-cell reanalysis of public datasets identifies an SPP1-expressing macrophage subset in breast cancer bone metastases and predicts its signaling ...

A machine-learning radiogenomic model predicts IL19 expression from glioblastoma MRI scans and separates patients into survival groups.

A new review consolidates evidence that the secreted protein DKK1 acts through multiple signaling routes and is associated with poor ...

A new review finds that O-GlcNAcylation links HPV-driven metabolic demand to growth and survival pathways in cervical cancer, but no ...

A review in the Journal of Translational Medicine examines how metabolic reprogramming enables regulatory T cells to drive immunosuppression in ...

A prospective study found that time-dependent diffusion MRI microstructural parameters distinguished mismatch repair deficient from proficient endometrial cancer with an ...

A new review maps how metabolic reprogramming controls gasdermin-mediated pyroptosis in tumors and outlines a four-level evidence framework for precision ...

A new review maps how artificial intelligence could overcome resistance and safety barriers in cancer stem cell-targeted cellular immunotherapy, while ...

A new review maps how the three secreted FGFBP proteins tune FGF signaling in physiology and act as divergent prognostic ...

A SCGB3A2-high tumor cell state in lung adenocarcinoma shows low angiogenesis and is associated with extracellular PGK2 and angiostatin signals.

Colorectal cancer prognosis has long been judged mainly by tumor stage and spread, but the immune cells living inside and ...

Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...

Researchers have introduced CORAL, a probabilistic deep generative model that leverages graph attention to integrate multiscale spatial transcriptomic, proteomic, metabolomic, ...

Cancer-associated fibroblasts deliver blood-borne cholesterol to pancreatic cancer cells and suppress T cell function through ANO6-dependent trogocytosis, a contact-based membrane ...

A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.

An exploratory study found that arterial wash-in on dynamic contrast-enhanced MRI was inversely correlated with CD3-positive stromal lymphocyte infiltration in ...

A new review examines how platelet-derived microparticles may worsen acute myeloid leukemia by transferring molecular cargo to cancer cells, and ...