Tag: Blood-brain barrier

A human stem-cell study shows that static membrane inserts and a flowing microfluidic blood-brain barrier chip give strikingly different answers ...

Researchers engineered lipid nanoparticles around the antihistamine hydroxyzine, achieving brain delivery of mRNA, CRISPR components and a radioprotective interleukin in ...

A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...

A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.

A new review proposes that the glucocorticoid-regulated protein Annexin A1 may connect HPA axis dysregulation, inflammation and blood-brain barrier integrity ...

A prospective study of 46 polytrauma patients found that concomitant traumatic brain injury was not associated with higher systemic neutrophil ...

A prospective phase II trial reports that orelabrutinib combined with sintilimab achieved a 60.7 percent response rate and a median ...

A new review proposes that reactive astrocytes with A1-like features may connect intestinal inflammation in IBD to comorbid depression through ...

A new review finds that neonatal and juvenile mice have carried nearly all Chandipura virus model research, supporting preclinical vaccine ...

A 23-year-old woman with insulin resistance and severe obesity arrived at an emergency department in Beirut with severe upper abdominal ...

BMC Neuroscience has issued an editorial expression of concern over a 2012 paper on liraglutide and lixisenatide, citing overlapping images.

A new review details how stimuli-responsive and biomimetic nanoparticles are being engineered to cross the blood–brain barrier and deliver therapy ...

Researchers built a human blood-brain barrier model combined with antiviral testing, validated it with anti-HIV drugs, showed TBEV crosses an ...

A new review in Discover Molecules synthesizes the chemistry, limited bioavailability, and gut-brain interactions of plant phenolic compounds, cautioning that ...

A new review argues that stroke is the endpoint of progressive vascular failure and that translational models can uncover biomarkers ...

A narrative review proposes that APOE ε4 amplifies diabetes-related cognitive decline across metabolic, vascular, and neurodegenerative layers, while α-Klotho may ...

A human cell-based in vitro study reports that highly protein-bound antivirals such as dolutegravir and efavirenz show reduced permeability across ...

A new review argues that crossing the blood-brain barrier is only the starting point of CNS drug delivery, with perivascular ...

A narrative mini-review argues that neurocysticercosis-related epilepsy arises from active parasite-host-neuron interactions, not inflammation alone.

DCE-MRI scans of 102 healthy people aged 19 to 85 reveal regional variation in blood–brain barrier permeability, with the age-related ...