Tag: Blood-brain barrier

A review in Cell Communication and Signaling examines how dynamic endothelial cell states influence the transition from vascular sprouting to ...

A review in Fluids and Barriers of the CNS links mitochondrial dysfunction to blood-brain barrier failure and explores therapeutic targets.

A comparative neuroimaging study reveals that diffusion-weighted and multi-echo arterial spin labeling MRI sequences yield opposing age-group differences in blood-brain ...

A new study identifies Skogholt’s disease as a model for primary brain fluid clearance failure, showing that choroid plexus dysfunction ...

A scoping review reveals that transcranial magnetic stimulation can temporarily increase blood-brain barrier permeability and promote fluid clearance, though clinical ...

A pharmacokinetic modeling study shows that blood-brain barrier permeability, rather than target binding rate, is the primary driver of dynamic ...

A study in Fluids and Barriers of the CNS finds that APPswe/PS1dE9 mice show no major integrative brain clearance deficits ...

A new carbon-11 labeled small molecule penetrates the blood-brain barrier but fails to show specific GLP-1R binding in preclinical PET ...

Aged female mice show less hypoxia-induced blood-brain barrier disruption than males, with the microglial receptor CD11c identified as a key ...

A comprehensive review reveals that neurovascular unit dysfunction actively drives ischemic stroke progression and identifies multi-target strategies to improve recovery.

A review in Fluids and Barriers of the CNS proposes a framework linking recurrent skin inflammation to neuroimmune buffering reserve ...

A study in Acta Neuropathologica Communications finds that early blood-brain barrier and glial changes in 3xTg-AD mice correlate with anxio-depressive-like ...

A review in Materials Today Bio details how precision nanoparticle systems can overcome the blood-brain barrier to target specific Alzheimer's ...

Weill Cornell Medicine has received more than $635,000 in first-year funding from the NIH's stroke and neurology institute to refine ...

A study of 409 participants found that sleep-disordered breathing is associated with elevated cerebrospinal fluid markers of blood-brain barrier dysfunction ...

A rat study reveals that fetal growth restriction from gestational protein deficiency impairs blood-brain and blood-CSF barrier integrity despite preserving ...

Stimuli that disrupt the blood-brain barrier induce human brain endothelial cells to secrete extracellular vesicles carrying both shared and stimulus-specific ...

A narrative review indicates that blood-brain barrier disruption in Alzheimer's disease increases cerebral antipsychotic penetration, triggering parkinsonian side effects and ...

A new review proposes matching lipid nanoparticle designs to specific Alzheimer's disease pathways, from neuronal BACE1 siRNA delivery to microglia-targeted ...

A narrative review argues that age-related chronic inflammation, macrophage-driven immune signalling and blood-brain barrier dysfunction may shift the concentration-effect relationship ...