Tag: tumor microenvironment

In a mouse and cell study, caloric restriction and fasting enhanced radiation's tumor-killing effects through the cGAS-STING pathway while protecting ...

RNA sequencing of 18 canine brain tumors reveals 45 genes expressed at different levels in French bulldogs compared with boxers ...

New cell and tissue research finds that the inflammatory cytokine IL-8 drives epithelial-mesenchymal transition and invasiveness in COPD-associated lung cancer ...

A study of 471 breast cancer patients found that a combined model of tumor-infiltrating lymphocytes-score and microvessel density-score exhibited better ...

Single-cell and spatial profiling of pancreatic tumors reveals a reinforcing loop between mature dendritic cells and regulatory T cells, mediated ...

A new narrative review in Frontiers in Oncology details how T cells, macrophages, neutrophils, B cells, NK cells, and dendritic ...

Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.

A six-gene endothelial cell signature built from single-cell RNA sequencing data predicts survival outcomes and reveals distinct tumor microenvironment communication ...

A computational study identified KRT14 and MMP10 as macrophage-associated candidate biomarkers of chemoradiotherapy response in esophageal squamous cell carcinoma.

A computational pan-cancer analysis links overexpression of the RPA gene family to worse survival and an immunosuppressive tumor microenvironment in ...

A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...

A preclinical study reports that ginseng-derived ginsenoside Rg3 binds Glut1 on tumor-associated macrophages, reprograms their metabolism, and enhances anti-PD-1 therapy ...

A new perspective argues that antigen-presenting fibroblasts in gastrointestinal tumors are reversible states whose immune role depends on unmeasured co-stimulatory ...

A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...

A new review details how engineered oncolytic viruses selectively kill tumors, ignite antitumor immunity, and where clinical translation still falls ...

A genome-wide knockout screen in E. coli identified metabolic adaptations, including deletions of nonglucose phosphotransferase systems, that enhance bacterial colonization ...

A newly published consensus standard defines unified workflows, validation criteria and drug testing protocols for breast cancer organoids grown from ...

A mouse study finds that neutrophils in breast cancer liver metastases suppress NK cell killing by contact-dependent downregulation of Eomes ...

Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...

A new study reports that the RNA m5C methyltransferase NSUN2 suppresses CCL5-driven CD8+ T cell recruitment in lung adenocarcinoma through ...