Tag: single-cell RNA sequencing

Researchers identified trauma-associated microglia that persist chronically after mouse traumatic brain injury and drive exaggerated inflammatory responses and tissue damage.

The ATLAS method imputes spatial single-cell maps of mouse brains and uncovers cell-type and regional composition differences between sexes and ...

A retrospective cohort of 199 pulmonary mycosis patients on triazole antifungals identified baseline liver enzymes and immunocompromised status as risk ...

A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...

A LASSO-based risk score built from oxidative stress-related genes predicts biochemical recurrence in prostate cancer, with LAMP5 knockdown reducing PC3 ...

A new review in Cell Regeneration explains why transient senescent cells support muscle repair while persistent senescence in aged or ...

A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...

A mouse study reports that CD34+ telocytes promote angiogenesis and wound healing by signaling to endothelial cells through Sema3c and ...

Whitehead Institute researchers profiled more than 600,000 cells to build the first whole-body single-cell transcriptome atlas of an adult vertebrate, ...

Deleting Trpv1 in myeloid cells worsened inflammation, fibrosis and barrier dysfunction in mice with high-fat diet-exacerbated chronic colitis, via a ...

A mouse study of traumatic brain injury found that astrocytes increase mitochondrial transfer to neurons via extracellular vesicles, a response ...

A new review summarizes how basal stem cells sustain lifelong olfactory epithelium renewal and how single-cell and organoid technologies are ...

A six-gene endothelial cell signature built from single-cell RNA sequencing data predicts survival outcomes and reveals distinct tumor microenvironment communication ...

A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...

A new study links macrophage STAT3 signaling to a paracrine inflammatory environment associated with ferroptosis-related cardiomyocyte injury in septic cardiomyopathy.

An integrative genomic and proteomic study identified seven new genetic loci and 23 genetically supported plasma proteins for age-related macular ...

Organoid and clinical single-cell data link a DHX58-positive, CD62L-positive stem-like T-cell state to immune checkpoint blockade responsiveness in gastric cancer.

An integrative analysis of human NOA transcriptomic data and a Utf1 conditional knockout mouse model identifies ACTRT2 and AKAP4 as ...

A multi-cohort study finds that five genes upregulated in clear cell renal cell carcinoma mark the immune microenvironment rather than ...

A single-cell study of pretreatment nasopharyngeal carcinoma biopsies identifies an SPP1-CD44 macrophage-tumor communication axis linked to chemotherapy tolerance.