Tag: single-cell RNA sequencing

Researchers kept human fibroblasts in a non-dividing state for six months and found that epigenetic and transcriptomic aging clocks accelerated ...

Spatial profiling of melanoma tumors reveals that lipid-associated macrophage neighborhoods drive immune exclusion and predict resistance to checkpoint inhibitor therapy.

Maternal immune activation primes adult male mice for insult-dependent vulnerability to Parkinson's disease-related injury.

A study integrating spatial transcriptomics, single-cell RNA sequencing and a 27-patient clinical cohort links peritumoral tertiary lymphoid structures and high ...

A computational workflow named CELLIA pairs statistical differential expression metrics with curated marker databases to improve the accuracy and consistency ...

Researchers have developed SAIGE-QTL, an efficient Poisson mixed-model framework that directly analyzes single-cell read counts to substantially expand expression quantitative ...

Researchers have identified a JUN-dependent MIF transcriptional program linked to a secretory epithelial cell state and predicted myeloid interactions in ...

Lab experiments show that HAPLN1 secreted by rheumatoid arthritis synovial fibroblasts pushes macrophages toward a proinflammatory M1 state through PI3K/AKT/NF-κB ...

A longitudinal single-cell study of ER-positive breast cancer links strong estrogen receptor signaling, ER-linked enhancer activity and expanding T cell ...

Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...

A single-cell reanalysis of public datasets identifies an SPP1-expressing macrophage subset in breast cancer bone metastases and predicts its signaling ...

A bioinformatics and laboratory study identified FKBP5, MYH6 and PROS1 as candidate endoplasmic reticulum stress-related feature genes in hypertrophic cardiomyopathy.

A study evaluates pulsed low-dose-rate radiotherapy and finds the spatial distance between SPP1-positive TAMs and GZMK-positive CD8-positive T cells is ...

A mouse study finds that conditioning transplant recipients, not donors, under chronic hypoxia prolongs heart allograft survival through a HIF2-dependent ...

A new review maps the biomarkers, transcriptomic signatures and methodological pitfalls involved in reliably identifying senescent vascular smooth muscle cells ...

A single-cell RNA sequencing study revealed an expansion of low-density neutrophils and altered immune communication in five patients with myasthenia ...

A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.

Single-cell RNA sequencing identified three mTOR-associated microglial populations in tuberous sclerosis complex and focal cortical dysplasia type II, with disease-specific ...

A single-protein synthetic organelle called the recordanelle preserves transient RNA expression records in human cells for at least five days, ...

Researchers report that a splice-modulating oligomer that reduces the long prolactin receptor isoform lowered pathogenic immune signatures in lupus patients' ...