Tag: single-cell RNA sequencing

A computational multi-omics study identifies CYP1A2 as a key hepatocyte-enriched target for eugenol in hepatocellular carcinoma, supported by transcriptomic and ...

Researchers developed a standardized protocol for isolating viable protoplasts from saffron tissues, enabling single-cell RNA sequencing and transient gene expression ...

A new computational workflow automatically extracts mesenchymal stromal cells from human dental pulp single-cell RNA-sequencing data, revealing distinct transcriptomic profiles ...

Researchers analyzing diabetic foot ulcer tissue data have identified four cellular senescence-related hub genes—EGFR, RAD51, CCNA2, and SUN1—and used them ...

New research identifies macrophages as key mediators linking aging and osteoporosis, revealing a bidirectional causal relationship driven by shared genetic ...

Researchers developed a seven-gene prognostic model linked to oxeiptosis in lung adenocarcinoma and demonstrated experimentally that silencing PSMD2 impairs tumor ...

A new single-cell atlas identifies ZBP1 as a critical inflammatory sensor in the nasal mucosa of allergic rhinitis patients, linking ...

A machine learning signature incorporating six histone deacetylase-related genes accurately stratifies hepatocellular carcinoma survival and reflects distinct immune microenvironment phenotypes.

Researchers identified ARG1 and PTEN as key mitotic catastrophe-related genes that are upregulated in ischemic stroke and validated by RT-qPCR.

A study of high-grade serous ovarian cancer links treatment stress and cellular injury to inflammatory remodeling marked by myeloid SPP1 ...

Single-cell RNA sequencing of human femoral head tissue reveals that alcohol-associated and glucocorticoid-associated osteonecrosis show distinct inflammatory, hypoxic and osteogenic ...

In a mouse model of autism spectrum disorder, treatment with hydroxysafflor yellow A improved autism-like behaviors and reduced neuroimmune-linked ADAM10 ...

An integrated transcriptomic atlas of the human maternal-fetal interface reveals a conserved inflammatory macrophage program governed by WTAP that is ...

A computational and experimental study identified CXCL12 as a core gene linking idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, ...

CellPatch combines cross-attention with heuristic gene patching to provide a lightweight, adaptable foundation model for single-cell RNA-sequencing analysis.

A new study uses single-cell RNA sequencing to explore the tumor microenvironment in NF2-related and sporadic vestibular schwannomas, identifying endothelial ...

An integrated single-cell transcriptomic analysis reveals that recurrent pregnancy loss is characterized by depleted placental trophoblasts, cytotoxic immune cell activation, ...

New loop-structured CAR-T cells targeting CD38 and CD123 show enhanced activity against heterogeneous acute myeloid leukemia in preclinical models.

Researchers introduced SWIMR, a statistical framework that integrates multiple single-cell RNA sequencing references to improve cell-type deconvolution accuracy in spatial ...

An integrated transcriptomic and single-cell analysis identified ARG1 and PLAUR as stress granule-related potential biomarkers in spinal cord injury.