Tag: microglia

In a mouse model of epilepsy, inhibiting or deleting hexokinase 2 enhanced microglial phagocytosis and reduced hippocampal paroxysmal discharges through ...

Aged female mice show less hypoxia-induced blood-brain barrier disruption than males, with the microglial receptor CD11c identified as a key ...

A single-cell transcriptomic study in mice reveals how periodontal inflammation exacerbates neuroinflammatory signaling and alters glial cholesterol pathways in early ...

A review in Aging Cell details how histone modifications link aging, metabolism, and neuroinflammation in Alzheimer's disease, proposing a framework ...

A review in Fluids and Barriers of the CNS proposes a framework linking recurrent skin inflammation to neuroimmune buffering reserve ...

A study in Acta Neuropathologica Communications finds that early blood-brain barrier and glial changes in 3xTg-AD mice correlate with anxio-depressive-like ...

A review published in Discover Immunity synthesizes evidence on the immunological mechanisms and neuroinflammatory pathways driving amyotrophic lateral sclerosis alongside ...

A study in Acta Neuropathologica Communications demonstrates that somatic TARDBP variants linked to FTLD-TDP-C disrupt morphology and increase microglia in ...

Histological analyses in male mice revealed subtle, paradigm-dependent cellular changes and limited spatial coupling between microglia and oligodendrocyte precursor cells ...

A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...

Human microglia fail to degrade extracellular tau, instead recycling internalized monomers back into the surrounding space and anchoring inflammatory fibrils ...

Repeated peripheral histamine injections in mice were associated with persistent, region-specific glial morphometric remodelling and attenuated behavioural and dopaminergic deficits ...

In Alzheimer-model mice, minimally invasive vagus nerve stimulation delivered right after orthopedic surgery reduced acute amyloid-beta accumulation, neuronal loss and ...

A new review argues that gut dysbiosis, immune hyperactivation and HPA axis disruption link idiopathic Parkinson's disease with the systemic ...

Single-cell RNA sequencing identified three mTOR-associated microglial populations in tuberous sclerosis complex and focal cortical dysplasia type II, with disease-specific ...

A new study reports that lncR-AK158273 suppresses microglial autophagy during LPS-induced neuroinflammation by upregulating Mst1 expression.

A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.

Researchers identified trauma-associated microglia that persist chronically after mouse traumatic brain injury and drive exaggerated inflammatory responses and tissue damage.

A new PLOS Biology Editorial argues that neurodegeneration research must look beyond dying neurons to the glia, vasculature, immune signals ...

A new commentary proposes that the mitochondrial protein PINK1, a central regulator of mitophagy, could act as a direct amyloid ...