Alzheimer’s Researchers Propose Mitochondrial PINK1 as an “Amyloid Switch” in Disease Pathogenesis
A new commentary proposes that the mitochondrial protein PINK1, a central regulator of mitophagy, could act as a direct amyloid ...
Tag: microglia
Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Inflammatory stimulation reshapes microglial vesicle miRNA cargo and modestly alters recipient cells
An in vitro study found that LPS-stimulated microglia enriched miR-155 and increased miR-34a in donor cells and their extracellular vesicles, ...
Astrocytes may drive chronic traumatic encephalopathy, scoping review finds
A PRISMA-guided scoping review of 40 studies argues that astrocytes act as early, active contributors to chronic traumatic encephalopathy rather ...
Microglial Activity Patterns Track Tau Buildup in Early Alzheimer’s Disease
A longitudinal PET and fMRI study links two distinct microglial activation signatures, structured by functional brain connectivity, to the spatial ...
Gasdermin D and E Play Distinct Roles in Photoreceptor Degeneration
A new review distinguishes a myeloid gasdermin D inflammatory relay from photoreceptor-intrinsic gasdermin E lysis in retinal degeneration and grades ...
Exercise-linked gene Ticam2 emerges as candidate ALS drug target in mice
A new mouse study links exercise-induced gene-expression changes to the microglial gene Ticam2, which shows potential as a therapeutic target ...
Glycolysis enzymes emerge as central players in Alzheimer’s brain energy failure
A new review argues that dysregulated glycolytic and pyruvate-metabolizing enzymes in specific brain cell types form a central axis linking ...
Microglial NLRP3 Inhibition Restores Memory After Hemorrhagic Shock in Mice
A mouse study finds that inhibiting the NLRP3 inflammasome specifically in microglia reduces hippocampal neuroinflammation and reverses cognitive deficits after ...
Plant Compound Ivangustin Pins Neuroinflammation on Covalent Hit at UBE2L3 Cys86
A new study reports that ivangustin, a sesquiterpene lactone from Inula japonica, suppresses microglial NF-κB signaling by covalently modifying cysteine ...
Aging Rewrites the Immune Landscape of the Cochlear Spiral Ganglion in Mice
A mouse study in GeroScience found that aged animals showed increased densities of immune- and glia-associated marker-positive cells in the ...
New Radiotracer Targets Brain Immune Cells With Unmatched Selectivity
Researchers validated 5-MOP, a tritium-labeled radioligand that binds CSF1R with 9.8 nM affinity and far greater kinase selectivity than the ...
Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
Thalamus Remodeling May Drive Neuropathic Pain After Spinal Cord Injury
A new review proposes that sustained thalamic remodeling, involving neuroimmune signaling, synaptic changes, and circuit reorganization, may help explain refractory ...
Gut Microbes, Immune Signals and the Inflammatory Road to Parkinson’s Disease
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...
Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
GPNMB–SMAD4 pathway links microglial inflammation to demyelination in diabetic cognitive dysfunction
A mouse and cell study finds that hyperglycemia lowers microglial GPNMB, disrupting its binding to SMAD4 and unleashing NF-κB-driven neuroinflammation ...
First Immune-Modulating Drug Trial Targets Neuroinflammation in Prodromal Parkinson’s Disease
A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...
Mitochondrial Cleanup and a DNA Sensor May Team Up to Drive Stroke Inflammation
A new review maps how mitophagy and the cGAS–STING pathway may jointly regulate post-stroke neuroinflammation through leaking mitochondrial DNA, based ...
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...
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