Tag: Ubiquitination

A 2026 review in Clinical Epigenetics examines how ubiquitination and acylation modifications interact to drive cancer drug resistance and identifies ...

Researchers reveal that the ubiquitin ligase MKRN1 protects colorectal cancer cells from cuproptosis by targeting the copper transporter SLC31A1 for ...

In mouse periodontal ligament stem cells, silencing the transcription factor ELK1 reduced STUB1-driven ubiquitin degradation of DLX2, raising osteogenic markers ...

A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...

New research in Cell & Bioscience shows that the G-protein subunit GNAZ suppresses lung adenocarcinoma by promoting HUWE1-mediated degradation of ...

A new review synthesizes how phosphorylation, ubiquitination, methylation, SUMOylation and O-GlcNAcylation form an interconnected network that controls the mitotic kinase ...

A new study reports that dihydroartemisinin suppresses melanoma by promoting ubiquitination and proteasomal degradation of the transcription factor SP1.

Human umbilical cord mesenchymal stem cell exosomes reduced kidney fibrosis in a preclinical model by delivering pVHL, which drives HIF-1α ...

A new study reports that hexokinase 2 promotes malignant phenotypes in colorectal cancer by enhancing UBE3A-dependent ubiquitination and degradation of ...

A new review explains how the bacterial effector SopB uses phosphatase, phosphotransferase and scaffolding activities to rewire host phosphoinositide signalling ...

TRIM29 promotes hepatocellular carcinoma growth by tagging the DAPK3 protein for proteasomal degradation, according to a new Cell Death Discovery ...

A new study reports that the ubiquitin ligase substrate receptor DCAF13 promotes hepatocellular carcinoma progression by targeting RCAN1.4 for degradation ...

A new study shows the E3 ligase UBE4B ubiquitinates and degrades VPS35, with opposing effects on cancer cell proliferation and ...

A Cell Division review maps how ubiquitination links diabetic stress to protein turnover, mitochondrial function, inflammation, and cell death in ...

A new cell-line study reports that the E3 ubiquitin ligase TRIP12 promotes protein translation and tumour-like growth in human cancer ...

A study in Clinical and Experimental Medicine reports that TRIM11 protects microglia from oxidative stress and ferroptosis during cerebral ischemia ...

A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...

A new study shows that ZNF593-driven SUMOylation stabilizes the stress-responsive protein ANKRD1, which activates MERTK-AKT survival signaling and promotes acquired ...

Calycosin reduced myocardial injury in diabetic mice in association with increased Rab7a-dependent lipophagy, while Rab7a silencing removed its protective effects ...

A 2026 review finds that the molecular scaffold HAX1 supports tumor growth, invasion, hypoxic adaptation and treatment resistance while showing ...