Review links protein modifications to ulcerative colitis mechanisms
A review finds that protein modifications regulate immune inflammation and epithelial barrier dysfunction in ulcerative colitis through mechanisms that remain ...
Tag: Ubiquitination
Ginsenoside RK3 triggers ferroptosis in osteosarcoma cells and boosts doxorubicin response
A preclinical study reports that ginsenoside RK3 suppressed osteosarcoma growth in cells and mouse xenografts by downregulating PRMT5, promoting GPX4 ...
TRIM27 Protein Drives Airway Inflammation in Asthma by Destroying TRAF3
A study in mouse and human airway cell models of asthma shows that the E3 ubiquitin ligase TRIM27 promotes airway ...
FBXO28 ubiquitinates BRD4 to fuel lung cancer cell malignancy
A study in non-small cell lung cancer models found that FBXO28 promotes proliferation, migration and invasion by ubiquitinating BRD4 and ...
White birch study links deubiquitinase BpUBP3 to pollen growth
A white birch study identified 56 deubiquitinase genes and found experimental evidence that BpUBP3 contributes to pollen germination and pollen-tube ...
New Study Identifies UBA1 as a Key Biomarker in Multiple Myeloma
A new study identifies UBA1 as a primary candidate biomarker for multiple myeloma by integrating ubiquitination and liquid-liquid phase separation ...
Two protein tags talk to each other and steer cancer’s fate
A new review in Genes & Diseases maps how arginine methylation and ubiquitination continuously regulate each other to influence cancer ...
Kidney Injury Gene Switch Discovered in Immune Cells Offers New Treatment Hope
A newly identified protein circuit in macrophages controls inflammatory kidney damage, and a natural compound can restore it.
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Hidden Protein Switches That Keep Bones in Balance May Reshape Osteoporosis Research
A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...
Hidden RNA Molecule Drives Ovarian Cancer by Stabilizing Two Key Oncoproteins
A long non-coding RNA called RBMS3-AS3 has emerged as a powerful molecular accomplice in ovarian cancer, according to a new ...
USP28 enzyme drives deadly blood vessel damage in sepsis, mouse study reveals
Researchers identify a USP28–NMMHC IIA signaling loop that accelerates endothelial cell death and multi-organ injury in septic mice, revealing a ...
Hidden Ubiquitin Switch That Lets Brain Tumors Evade Immune Attack Is Revealed
New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...
Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Researchers have discovered that the protein HERC4 acts as the critical molecular switch that converts TNF survival signalling into cell ...
Beyond the On-Off Switch: Chemical Tags on KRAS Reshape Cancer Drug Design
A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...
Molecular Tags of Cell Death: How E3 Ubiquitin Ligases Steer Necroptosis in Cancer
A new review explains how E3 ubiquitin ligases attach molecular tags to the necroptosis machinery, shaping both cancer development and ...
Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
Fish-Specific Ubiquitin Ligase NHRE3 Helps Virus Evade Antiviral Defenses by Degrading ISG15
Researchers identified a fish-specific E3 ubiquitin ligase, NHRE3, that suppresses antiviral immunity in grass carp and rare minnows by tagging ...
Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
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