Liver Cancer’s Hidden Brake: How A20 Marks a Key Tumor Protein for Destruction
New research reveals that the ubiquitin-editing enzyme A20 promotes the degradation of the pro-tumor protein osteopontin in hepatocellular carcinoma, offering ...
Tag: Ubiquitination
Tight Junction Protein Revealed as Hidden Brake on Kidney Cancer Growth
Researchers report that the tumor-suppressive protein TJP2 stabilizes TIMM21, which boosts SPRY4 and dampens ERK1/2 signaling to restrain clear cell ...
Cell cycle clock controls RNA methylation through a hidden ubiquitin code
A new Nature Chemical Biology study reveals that the ubiquitin ligase RLIM tags the m6A writer METTL14 with noncanonical K27-linked ...
Scientists Uncover Molecular Switch That Helps Prostate Cancer Spread to Bone
A new study reveals that an AURKA-driven phosphorylation and SUMOylation cascade stabilizes the protein SPICE1, fueling prostate cancer's spread to ...
Enzyme USP45 Drives Liver Cancer Growth by Stabilizing Oncoprotein CIAP2
Researchers in China have shown that the deubiquitinating enzyme USP45 promotes hepatocellular carcinoma progression by removing K48-linked ubiquitin chains from ...
Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth
Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...
MCM8 Accelerates Colorectal Cancer by Inhibiting Ubiquitination
In a groundbreaking study published in the Journal of Translational Medicine, researchers have unveiled the significant role of a protein ...
GlcNAcylation Enhances H2BK120 Monoubiquitylation Process
In a groundbreaking study, researchers have delved into the intricate mechanisms of transcriptional regulation facilitated by the modification of histones, ...
