Tag: Parkinson’s disease

A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...

A prospective multicenter registry study revealed that nearly one-third of infusion therapies for Parkinson's disease were discontinued, while deep brain ...

A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...

A study of 234 Parkinson's disease patients identified choroid plexus enlargement as an independent imaging correlate and candidate predictor of ...

A Frontiers editorial outlines how EEG-based biomarkers, machine learning and BCI technologies could support personalised mental healthcare while facing low ...

A study in Parkinson’s disease cohorts found sex-dependent associations among peripheral inflammation, glymphatic system-related imaging markers, and cognitive and motor ...

Repeated serum proteomics in 166 Parkinson's patients identified six protein-clinical associations linked to clinical worsening across motor, cognitive, and treatment ...

A systematic review of 26 studies in 1,057 Parkinson's patients links singing interventions to gains in voice, breathing, gait and ...

A capsaicin-coated magnetoelectric particle that generates electrical pulses in the stomach stimulated the vagus nerve and eased motor symptoms and ...

Repeated peripheral histamine injections in mice were associated with persistent, region-specific glial morphometric remodelling and attenuated behavioural and dopaminergic deficits ...

A new review argues that gut dysbiosis, immune hyperactivation and HPA axis disruption link idiopathic Parkinson's disease with the systemic ...

A narrative review finds corneal nerve measurements taken with in vivo confocal microscopy show the strongest evidence as an adjunctive ...

De novo designed microproteins, built computationally to bind toxic amyloid fibrils and restore mitochondrial function, are emerging as promising candidates ...

A language-model-based AI called Quest2Dx screens for Parkinson's disease using self-reported health questionnaires, achieving AUROCs up to 0.977 and transferring ...

In a small exploratory study, Parkinson's disease patients had smaller deep cervical lymph nodes than healthy controls, and node measurements ...

A new rat study reports that chitosan-coated selenium nanoparticles carrying Mucuna pruriens seed extract improved motor function, antioxidant levels, and ...

Parkinson's patients who recognize the identity of their presence hallucinations show more advanced disease, worse motor function and stronger fronto-temporal ...

A new PLOS Biology Editorial argues that neurodegeneration research must look beyond dying neurons to the glia, vasculature, immune signals ...

A human stem-cell study shows that static membrane inserts and a flowing microfluidic blood-brain barrier chip give strikingly different answers ...

A letter to the editor argues that a fifteen-patient staged lesioning study lacked a comparator arm, blinded assessment, and medication ...