Tag: Parkinson’s disease

A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.

A multimodal MRI study of 76 Parkinson's patients found the DTI-ALPS index covaried with regional thalamic tissue susceptibility and age ...

A pilot cross-sectional study found significantly elevated total α-synuclein in non-stimulated basal tears of Parkinson's disease patients, with moderate diagnostic ...

A study of 38 people with Parkinson's disease and 38 matched controls found that emotion recognition and valence ratings from ...

In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response ...

A hemispheric-gradient EEG microstate and muscle activity both dip during freezing of gait in Parkinson's disease, and EMG features can ...

Editors of a Frontiers in Molecular Neuroscience Research Topic survey studies linking synaptic, immune and systems-level molecular mechanisms to neurological ...

A new review in Frontiers in Medical Technology surveys how optogenetics has advanced the study of neural circuits in neurodegenerative ...

A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...

In a 6-OHDA mouse model of Parkinson's disease, striatal 5hmC levels and linked synaptic gene programs changed dynamically at two ...

A rat study finds that eight weeks of daily D-serine at 200 mg/kg produces kidney inflammatory infiltrates and biological alterations, ...

A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...

A scoping review of twelve studies finds low back pain affects an estimated 40% to 88% of people with Parkinson's ...

A narrative review finds that testosterone replacement therapy in Parkinson's disease shows context-dependent neuroprotective and neurotoxic effects in preclinical studies, ...

A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...

Multimodal MRI shows that nigrosome-1 neuromelanin loss and iron changes, with inverted neuromelanin-iron coupling, best mark Parkinson's disease nigral degeneration.

Kurarinone protected neurons from ferroptosis in cellular and mouse models of Parkinson's disease by activating an ERα-associated NRF2/FTH1 iron-sequestration pathway.

A systematic review of six randomized trials finds preliminary cognitive gains from probiotics in older adults with existing deficits, while ...

In an MPTP mouse model of Parkinson's disease, males developed stronger depressive- and anxiety-like behaviors alongside greater nigrostriatal degeneration, hippocampal ...

A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.