Glioblastoma Detected After Deep Brain Stimulation
A case report and literature review describe the development of glioblastoma two years after deep brain stimulation for Parkinson's disease, ...
Tag: Parkinson’s disease
EEG Deep Learning Framework Classifies Parkinson’s Disease with Interpretable Analysis
A new attention-based deep learning framework classifies Parkinson’s disease from resting-state EEG signals with high accuracy and provides interpretable sub-band ...
Review Links Brain Lymphatic Drainage to Parkinson’s
A review in npj Parkinson's Disease examines the brain lymphatic drainage system's role in Parkinson's disease pathogenesis.
Algerian Parkinson’s Study Identifies Rare Variants in Six Candidate Genes
An exploratory study of 19 Algerian patients with Parkinson’s disease identified rare variants in six candidate genes, highlighting the genetic ...
Nine Large Language Models Evaluated on Professional Parkinson’s Disease Clinical Tasks
A benchmark evaluation of nine large language models across 200 professional Parkinson's disease tasks revealed minimal separation in factual accuracy ...
Speech and Language Analysis Identifies Parkinson’s Disease and Cognitive Impairment
An automated framework combining acoustic and linguistic speech features achieved high accuracy in detecting Parkinson's disease and characterizing associated mild ...
RBD Status Classifies Parkinson’s Disease Subtypes in Small Cohort
A study of 20 early Parkinson’s disease patients found that REM-sleep behavior disorder status correctly classified 85% of individuals into ...
Lower BCAA Levels Linked to Higher Parkinson’s Risk
A prospective cohort study of 374,751 UK Biobank participants found that higher circulating levels of branched-chain amino acids are associated ...
Study Finds Lower Lipid Profiles Among Parkinson’s Disease Patients in Ethiopia
A comparative cross-sectional study at Tikur Anbessa Specialized Hospital revealed significantly lower lipid levels in Parkinson’s disease patients compared to ...
Maternal immune activation primes adult offspring for insult-dependent Parkinsonian vulnerability in male mice
Maternal immune activation primes adult male mice for insult-dependent vulnerability to Parkinson's disease-related injury.
Multiregional Brain Sensing Predicts Parkinson’s Motor Fluctuations in Animal Models
A multiregional neural sensing framework using machine learning predicted Parkinson's disease motor fluctuations with nearly ninety percent accuracy across animal ...
Digital Mobility Outcomes Support Frailty Prevention and Monitoring Across Healthcare Stages
A scoping review of 23 studies demonstrates that wearable digital mobility outcomes can capture real-world mobility changes to support frailty ...
Impaired Optokinetic Nystagmus Correlates With Freezing of Gait in Parkinson’s Disease
In a study of 251 patients with Parkinson’s disease and 46 healthy controls, researchers found that reduced optokinetic nystagmus gain ...
Engineered Alpha-Synuclein Mouse Models Reshape Parkinson’s Therapy Testing
A new review details how engineered alpha-synuclein mouse models with defined biochemical defects are transforming Parkinson's disease therapy development.
Phosphorylation of 14-3-3γ Impairs Its Ability to Limit Alpha-Synuclein Aggregation
A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...
Computational Model Explains Brain Wave Coupling in Parkinson’s Disease
A computational model of the subthalamic nucleus reveals that synchronized bursting among excitatory neurons drives pathological phase-amplitude coupling in Parkinson's ...
VTA dopamine loss disrupts memory-guided hindlimb control in mice
Mice with ventral tegmental area dopamine lesions stomp and graze obstacles with their hindlimbs while forelimb control remains intact, implicating ...
BDNF Supplementation Worsens Graft-Induced Dyskinesia in Parkinsonian Rats
In a CRISPR rat model of Parkinson's disease, replenishing BDNF unexpectedly exacerbated graft-induced dyskinesia through mechanisms involving an immature phenotype ...
Review Explores Role of Somatic Mutations in Neurodegenerative Disease Mechanisms
A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...
Real-World Study Tracks Discontinuation and Optimization in Parkinson’s Device Therapies
A prospective multicenter registry study revealed that nearly one-third of infusion therapies for Parkinson's disease were discontinued, while deep brain ...
