Neonatal Mice Show a Brief Window of Increased Blood-Brain Barrier Permeability
A study in neonatal mice reveals that the blood-brain barrier undergoes a transient, size-restricted increase in small-molecule permeability during early ...
Tag: Neurovascular unit
Mitochondrial Dysfunction Linked to Blood-Brain Barrier Failure
A review in Fluids and Barriers of the CNS links mitochondrial dysfunction to blood-brain barrier failure and explores therapeutic targets.
Neurovascular Unit Failure Actively Drives Ischemic Stroke Progression and Brain Damage
A comprehensive review reveals that neurovascular unit dysfunction actively drives ischemic stroke progression and identifies multi-target strategies to improve recovery.
Neuroimmune buffering reserve at the neurovascular unit: a CLDN5- and microglia-centred view of recurrent peripheral inflammation
A review in Fluids and Barriers of the CNS proposes a framework linking recurrent skin inflammation to neuroimmune buffering reserve ...
Sensory and Metabolic Networks in Stroke Offer Investigational Clues for Therapy
A narrative review examines how sensory nerves, immune responses, and metabolic pathways intersect during ischemic stroke while urging rigorous validation ...
Spinal Cord Vascular Profiling Uncovers Endothelial Dysfunction and Fibroblast Remodeling in ALS
Single-nucleus transcriptomic profiling of human amyotrophic lateral sclerosis tissues reveals marked blood-spinal cord barrier breakdown and specialized perivascular fibroblast remodeling ...
Neurons Do Not Die Alone: Why Neurodegeneration Is a Disease of the Tissue Around Them
A new PLOS Biology Editorial argues that neurodegeneration research must look beyond dying neurons to the glia, vasculature, immune signals ...
Extracellular vesicles emerge as biomarkers and therapies for vascular dementia
A structured narrative review maps extracellular vesicle evidence in vascular cognitive impairment and dementia, finding therapeutic research still largely preclinical ...
Gut Microbiota Signals Drive Pericyte Injury and Vascular Damage in Alzheimer’s Mice
A mouse study finds that depleting gut microbiota or neutralizing IL-17A protects cerebrovascular pericytes and the blood-brain barrier in an ...
Mitochondrial Cleanup and a DNA Sensor May Team Up to Drive Stroke Inflammation
A new review maps how mitophagy and the cGAS–STING pathway may jointly regulate post-stroke neuroinflammation through leaking mitochondrial DNA, based ...
Mitochondrial transfer emerges as a potential neurotherapeutic strategy for CNS disorders
A new review maps how intercellular mitochondrial transfer and transplantation could treat central nervous system disorders, while flagging dye-labeling artifacts ...
Sonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link
A GeroScience review proposes that an age-related imbalance between protective Sonic hedgehog signalling and degradative MMP activity may link neurovascular ...
Kidney metabolic stress and Klotho resilience converge on the brain’s vasculature
A new review proposes that elevated homocysteine and declining Klotho may jointly determine how kidney dysfunction translates into blood–brain barrier ...
Circadian-Linked Endothelial State Offers New Clue to Stroke Recovery
A newly identified PI16-expressing reactive endothelial cell state with strong circadian gene activity supports neuronal survival and reduces brain injury ...
Modified Dioscorea Pills improve cognition in rat cerebral hypoperfusion model
A 14-herb Chinese medicine improved learning and memory and altered hippocampal injury and vascular markers in rats with experimentally induced ...
Patient-derived stem cells and organoids open a new window on Moyamoya disease
A new review maps how patient-derived induced pluripotent stem cells and three-dimensional vascular and neurovascular organoids are transforming Moyamoya disease ...
Mitochondrial Metabolic Remodeling Drives Blood–Brain Barrier Dysfunction After Repetitive Mild Traumatic Brain Injury
A new review argues that recurrent mitochondrial metabolic stress, redox imbalance, and inflammatory signaling converge on the neurovascular unit to ...
ApoE4 May Raise Risk of Cognitive Decline From Small Vessel Disease, Review Finds
A new narrative review argues that ApoE4 acts as a context-dependent susceptibility modifier in cerebral small vessel disease rather than ...
Cholinergic Neurons Control Brain Blood Flow and Fluid
In a groundbreaking study published in Nature Communications, researchers have unveiled an intricate and previously underappreciated role of cholinergic basal ...
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