Machine Learning Identifies Three ALS Progression Patterns
A new machine learning framework identifies three distinct progression patterns in ALS patients, offering a tool for earlier prognostic assessment ...
Tag: neurodegenerative disease
Pilot Study Links Environmental Factors to Lewy Body Dementia Risk
An exploratory remote pilot study found that metal exposure, alcohol, and smoking were associated with higher Lewy body dementia risk, ...
Algerian Parkinson’s Study Identifies Rare Variants in Six Candidate Genes
An exploratory study of 19 Algerian patients with Parkinson’s disease identified rare variants in six candidate genes, highlighting the genetic ...
Deep Cervical Lymph Node Size May Track Parkinson’s Disease Severity
In a small exploratory study, Parkinson's disease patients had smaller deep cervical lymph nodes than healthy controls, and node measurements ...
SEL1L emerges as a molecular gatekeeper of cellular protein quality control
A systematic review links the SEL1L-HRD1 quality control complex to neurodegeneration, cancer, metabolism and immunity.
Inflammatory stimulation reshapes microglial vesicle miRNA cargo and modestly alters recipient cells
An in vitro study found that LPS-stimulated microglia enriched miR-155 and increased miR-34a in donor cells and their extracellular vesicles, ...
Brain FDG PET Scan Flags Cognitive Decline Risk in Psychiatric Patients
A study of 34 psychiatric patients with confirmed cognitive symptoms found that brain FDG PET identified those at risk of ...
Small Molecule Strategy Degrades Many Disease Proteins at Once in Cell Models
A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...
Parkinson’s Disease Raises Fracture Risk, and Osteoporosis Care Must Keep Up
A new perspective article argues that osteoporosis prevention deserves far more attention in people with Parkinson's disease, especially when dementia ...
Federated, explainable AI framework classifies Alzheimer’s disease from MRI and clinical data
A federated learning framework combining MRI and clinical data classifies Alzheimer's disease with reported accuracy up to 94.1 percent while ...
RNA Tag m6A Emerges as a Master Switch in Gene Control, Stress and Disease
A review in Nature Reviews Molecular Cell Biology explains how the RNA modification N6-methyladenosine regulates gene expression, enables cellular adaptation, ...
GLIS3 regulates astrocyte differentiation in human stem cells
Experiments in mouse-derived astrocytes and human embryonic stem cells identify GLIS3 as an upstream regulator of astrocyte differentiation and neural ...
Tiny Brain Vesicles in Blood Could Transform Diagnosis of Neurological Disease
A new review details how extracellular vesicles carrying brain-derived proteins and RNAs could enable minimally invasive diagnosis of Alzheimer's, Parkinson's, ...
Apigenin, a Common Plant Flavonoid, Emerges as a Multi-Target Defender of the Aging Brain
A new review in Molecular Biology Reports details how the dietary flavonoid apigenin combats oxidative stress, neuroinflammation, mitochondrial dysfunction, and ...
AI That Reads Brain Scans Fairly: New Method Strips Age Bias From Alzheimer’s Deep Learning Models
A German research team has shown that a GLM-based residualization method removes age confounding from MRI-based Alzheimer's classifiers far more ...
DNA Nanosensors Paired With AI Aim to Catch Brain Inflammation Early
A new review in Results in Chemistry details how programmable DNA nanobiosensors combined with artificial intelligence could enable early detection ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
One Wet-Lab Measurement May Be Enough to Steer AI-Designed ALS Gene-Silencing Drugs
A biophysics-informed machine learning framework predicts how effectively antisense oligonucleotides knock down ALS-relevant genes using only a single experimental measurement ...
Gut microbes may hold the key to Alzheimer’s and Parkinson’s disease
For decades, scientists have treated Alzheimer's and Parkinson's disease as problems of the brain alone. A new review published in ...
Brain Chemistry Meets Immune Fire: How Neurotransmitters Steer the NLRP3 Inflammasome
A new narrative review maps the complex, context-dependent crosstalk between neurotransmitter systems and the NLRP3 inflammasome, revealing bidirectional regulation with ...
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