Hypoxia Silences an Invasion-Braking Gene in Oral Cancer via a Nuclear LOX-H1.5 Pathway
Researchers report that hypoxia activates a nuclear LOX-H1.5 decrotonylation axis that represses the DAG1 gene and promotes invasive progression in ...
Tag: epigenetics
Epigenetic Split in AKAP12-LMOD1 Axis Shapes Colorectal Cancer Stroma and Epithelium
A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...
Enzyme Rivalry in Tumors: How Arginine Methyltransferases Cooperate and Compete in Cancer
A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...
Histone Lactylation Drives ALKBH5 to Worsen Cardiac Hypertrophy via ATF6 Demethylation
A study in Cell Biology and Toxicology reports that H3K18 lactylation promotes ALKBH5 transcription, which stabilises ATF6 mRNA through m6A ...
BRCA1/2 Mutation Carriers Show Fewer Active Ribosomal DNA Copies in Blood
Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...
Gene Screens in Aged Mice Reveal Two Distinct Routes to Restore Tumor-Fighting T Cells
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
EBV-driven lymphoproliferative disorders show disrupted DNA methylation patterns
A new review links EBV-driven lymphoproliferative disorders to disrupted DNA methylation and outlines emerging epigenetic treatment strategies.
Rumpelstiltskin Protein Guards Genome Boundaries in Fruit Flies
A new study finds that the Drosophila protein Rumpelstiltskin maintains the Homie insulator barrier and shapes Polycomb domain interactions in ...
Omega-3 Fatty Acids Linked to Better Lung Health in Smokers Through Epigenetic Recovery
A large observational study of former and current smokers found that higher blood omega-3 fatty acids were associated with better ...
Mitochondrial DNA methylation signals in WGBS are mostly technical artifacts
A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, ...
DNA Methylation Links Failing Fat Cell Formation to Obesity and Diabetes
A new review describes how aberrant DNA methylation and premature senescence of fat cell precursors drive adipose tissue dysfunction in ...
How metabolism may reshape DNA methylation across the cardiovascular–kidney–metabolic continuum
A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes ...
Maternal Diabetes Linked to Cranial Neural Tube Defects via Elevated H3K18cr
A mouse study links maternal diabetes-induced cranial neural tube defects to elevated H3K18 crotonylation and silencing of AKT and PIKFYVE.
Mutant KMT2D Rewrites Chromatin and Immune Signals to Drive Follicular Lymphoma
A new study shows that loss-of-function mutations in the chromatin regulator KMT2D promote follicular lymphoma by lowering H3K9me3 marks, activating ...
Gut Microbes Send Chemical Signals That Shape Cancer and Metabolic Disease
A new review details how microbiome-derived metabolites such as short-chain fatty acids, secondary bile acids, and tryptophan derivatives regulate host ...
EZH2 Blockade Restores Glioblastoma Sensitivity to Radiotherapy in Preclinical Models
A new study reports that irradiation stabilizes EZH2 in glioblastoma, driving H3K27me3-mediated DEPTOR repression and mTOR activation, and that EZH2 ...
How Histone Tweaks Help Deadly Fungi Evade Drugs and Hosts
A new review in Current Genetics details how histone methylation, acetylation, and demethylation regulate virulence, stress responses, and drug resistance ...
Chemotherapy’s hidden toll on sperm DNA comes under review
A new review examines how chemotherapeutic agents damage sperm DNA and germ cells, and what fertility preservation options exist for ...
DNA Methylation Test Matches Flow Cytometry for Measuring Immune Cells in Blood
A new study reports that quantifying immune cells from DNA methylation patterns matches clinical flow cytometry and CBC results within ...
SWI/SNF Chromatin Complex Gene Expression Mapped Across 33 Cancer Types
A pan-cancer analysis of about 11,000 TCGA samples maps the expression of all 29 SWI/SNF chromatin remodeling genes across 33 ...
