Tag: epigenetics

An EWAS in a Singapore-based Asian cohort identified three novel DNA methylation markers for carotid intima-media thickness and linked one ...

In a 6-OHDA mouse model of Parkinson's disease, striatal 5hmC levels and linked synaptic gene programs changed dynamically at two ...

A new review describes how the long non-coding RNA MALAT1 drives leukemia cell survival, proliferation and chemotherapy resistance in acute ...

A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell dysfunction ...

Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state ...

A six-year epigenome-wide association study in older adults without type 2 diabetes found that higher vitamin B12 intake was associated ...

A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...

A new study finds that CD14-positive monocytes from rheumatoid arthritis and psoriatic arthritis patients show distinct inflammatory, metabolic, epigenetic and ...

A new review proposes that polyendocrine metabolic ovarian syndrome arises from prenatal epigenetic programming that is unmasked by puberty and ...

A bioinformatic drug-repurposing study points to the epigenetic regulator DNMT3A in synovial cells as a candidate driver of osteoarthritis inflammation, ...

A new preclinical study reports that the Astragalus compound astragaloside IV reduces hepatic fat accumulation in mice and human liver ...

A 55-CpG DNA methylation signature developed from bone marrow samples and validated in an independent cohort appears to predict AML ...

A combination of low-dose metformin and valproic acid reprograms the metabolism of drug-tolerant persister cells in gastric and liver cancer ...

Structure-guided screening has yielded two compounds that selectively interfere with CDCA7 binding to hemi-methylated DNA, partially recapitulating phenotypes of CDCA7 ...

A new review describes how UV radiation, chemical exposure and hormonal changes can alter melanin production through epigenetic mechanisms such ...

A new review synthesizes animal and human evidence suggesting that micro- and nanoplastics may impair oocyte development through several molecular ...

Human stem cell-derived neural progenitor cells reveal that unliganded thyroid hormone receptor maintains chromatin homeostasis through the NuRD complex and ...

A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.

A new mini-review outlines how epigenetic silencing of NK-activating ligands helps urothelial carcinoma evade immune attack and how DNMT and ...

A UK Biobank study of 181,955 participants links better cardiovascular health and slower biological aging to lower chronic respiratory disease ...