Hospital Study Links Specific Torque Teno Viruses to Late-Life Vulnerability
A study of hospitalized older adults reveals that specific Torque teno virus species associate with cognitive impairment, frailty, and epigenetic ...
Tag: epigenetics
Multi-Omics Study Identifies Mitochondrial Genes and Epigenetic Markers in Cardiac Arrest
A multi-omics study identified five mitochondrial genes, including GATM, with directional genetic and epigenetic associations with cardiac arrest risk.
TET2 controls AGO2, linking DNA methylation to RNA regulation in leukaemia
A new study shows that the leukaemia gene TET2 directly controls the RNA-regulating protein AGO2, and reducing AGO2 impaired leukaemia ...
Histone lactylation boosts bone formation in postmenopausal osteoporosis
A new study reveals that histone lactylation promotes bone formation in postmenopausal osteoporosis by stabilizing the SMAD1 protein through an ...
Review Evaluates HDAC1 as a Potential Therapeutic Target in Cholangiocarcinoma
A review highlights Histone Deacetylase 1 as a promising epigenetic target to address drug resistance and poor prognosis in cholangiocarcinoma.
Marsupial DNA Repair Gene MLH1 Retains Functional Retrocopies Across Multiple Lineages
Scientists have discovered that marsupials maintain functional, expressed retrocopies of the essential DNA repair gene MLH1 to compensate for parent-of-origin ...
Pathway Epigenetic Model Uncovers Cross-Tissue DNA Methylation Patterns Linked to Asthma
A cross-tissue machine learning framework utilizing Gene Ontology pathway-level DNA methylation scores accurately identified asthma status across multiple airway epithelial ...
PSMB7 Linked to Lung Adenocarcinoma Progression, Radiation Resistance, and Prognosis
Researchers evaluated PSMB7 across multiple datasets and cell lines, identifying it as an independent prognostic biomarker linked to immune microenvironment ...
Review Highlights Epigenetic and Metabolic Remodeling in Pulmonary Arterial Hypertension
A scientific review details how disrupted metabolic pathways regulate epigenetic remodeling in pulmonary vascular cells during pulmonary arterial hypertension.
Study Links Placental Sex Chromosome DNA Methylation to Early-Onset Preeclampsia
Researchers analyzing 843 placental samples have identified sex-linked DNA methylation differences associated with early-onset preeclampsia across both male and female ...
Multi-Omics Study Prioritizes Novel Lung Cancer Genes in East Asian Populations
A multi-omics study using East Asian-specific models has prioritized novel susceptibility genes and epigenetic markers linked to lung cancer risk.
Cell-Type-Specific Transcriptional and Epigenetic Regulation in Substance Use Disorder
A new Frontiers collection of seven studies shows that addiction's molecular changes are cell-type-specific, spanning epigenetics, RNA modification, and human ...
Researchers Uncover RNA Modification Mechanism Driving Esophageal Squamous Cell Carcinoma Growth
Investigators have identified an epigenetic mechanism in esophageal squamous cell carcinoma where METTL3-mediated m6A modification of the long non-coding RNA ...
Microbiome Remodeling and Host Epigenetic Alterations Characterize Gastric Cardia Precursor Lesions
A cross-sectional multi-omics study demonstrates that mucosal microbiome remodeling co-occurs with host epigenetic alterations across precancerous stages of gastric cardia ...
Epigenetic Inhibitor JQ1 Curbs Aggressive Synovial Cells in Rheumatoid Arthritis
A preclinical study shows that the BET inhibitor JQ1 suppresses the hyperproliferation, invasiveness, and inflammatory activity of rheumatoid arthritis synoviocytes ...
Claudin-1 Distinguishes Stress-Induced Premature Senescence in Human Vascular Smooth Muscle Cells
Researchers have identified claudin-1 as a cell-specific marker that distinguishes stress-induced premature senescence from replicative senescence in human vascular smooth ...
Aging reframed as a shift from biological order to widening regulatory chaos
A new theoretical framework proposes that aging unfolds as rising regulatory dispersion and declining systemic coherence across biological scales.
Loss of Dmrt1 Triggers Epigenetic Feminization in Male Tongue Sole
Deficiency in the conserved vertebrate master male-sex-determining gene dmrt1 leads to extensive alterations in DNA methylation in the brain and ...
Crotonylation Boost Keeps Aging Stem Cells Fighting Gut Inflammation
Researchers report that restoring the chemical tag lysine crotonylation through sodium crotonate rejuvenates aging adipose-derived stem cells and improves their ...
Immune gene KDM6A drives heart failure after attack, mouse study shows
A mouse and patient study finds that hematopoietic loss of the X-linked gene KDM6A worsens cardiac recovery after myocardial infarction ...
