Tag: epigenetics

A chromosome-wide analysis of 89 human brain methylomes finds that the combined methylation of female X chromosomes is globally lower ...

Using native long-read nanopore sequencing, researchers have simultaneously mapped 5mC and 5hmC across the whole genome of human neuronal nuclei, ...

A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...

DNA methylation at the LINC01354 and LINC01510 long non-coding RNA loci rises with tumor stage, grade and metastatic spread in ...

Engineered macrophages that transfer mitochondria to Schwann cells restored erectile function in a rat model of cavernous nerve injury by ...

A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...

A study identifies an SP1/P300/TRAF3IP3 signaling axis that links promoter-specific chromatin remodeling to persistent ERK activation in glioblastoma.

A study of healthy volunteers aged 1.5 to 71 found that urinary levels of active DNA demethylation products decline with ...

A new review proposes combining enzymes fermented from agricultural waste with artificial nanozymes to degrade persistent pesticides such as chlorpyrifos ...

A narrative review proposes that mitochondrial injury links varicocele-related oxidative stress and sterile inflammation, while stressing that the full pathway ...

A genome-wide study of human cells finds 9,006 differentially methylated CpG sites and 1,526 differentially methylated regions during osteoclast differentiation.

A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...

A new review in Frontiers in Endocrinology synthesizes molecular biomarkers, including DNA methylation and liquid biopsy indicators, that may help ...

A methylation comparison of human gingival fibroblasts, their derived iPSCs and an embryonic stem-cell reference found broad pluripotent-state convergence alongside ...

A cell study finds that the enzyme BCAT1, elevated in endometriosis tissue, promotes proliferation and migration of ectopic endometrial stromal ...

A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...

A new review argues that conserving medicinal plants under climate change requires protecting adaptive genomic variation, not just species or ...

A urine-based DNA methylation marker, TAGMe, was associated with poorer outcomes in urothelial carcinoma and improved preoperative risk prediction in ...

A study of Indian cervical cancer patients links THOR hypermethylation to hTERT reactivation and reduced menin recruitment, independent of HPV ...

Gladstone Institutes physician-scientists Melanie Ott and Alex Marson have been elected to the National Academy of Medicine in recognition of ...