A mechanistic review evaluates how stereotactic body radiotherapy reshapes the pancreatic ductal adenocarcinoma microenvironment by simultaneously triggering localized immune activation ...
A narrative review argues that MEK inhibitors have transformed treatment of NF1-associated plexiform neurofibromas, but predominantly partial responses, toxicity, and ...
A multicenter study found that FH-deficient kidney cancer patients with DNA damage repair gene mutations showed significantly higher response rates ...
A YIGSR-modified liposome co-loaded with doxorubicin and 5F showed stronger cytotoxicity, higher cellular uptake and greater tumor accumulation than non-targeted ...
A new review finds that combining SGLT2 inhibitors with GLP-1 receptor agonists in heart failure is mechanistically plausible and generally ...
In a controlled mouse study, combining ivermectin with two low doses of gamma-radiation reduced Schistosoma mansoni egg burdens, liver enzyme ...
A new systematic review and meta-analysis finds that gold nanoparticle-mediated photothermal therapy raised tumor temperatures by about 15 degrees Celsius ...
A narrative review consolidates preclinical evidence that the carotenoid astaxanthin inhibits breast cancer cell proliferation, metastasis and angiogenesis, while stressing ...
A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...
A new review details how engineered oncolytic viruses selectively kill tumors, ignite antitumor immunity, and where clinical translation still falls ...
A new study reports that irradiation stabilizes EZH2 in glioblastoma, driving H3K27me3-mediated DEPTOR repression and mTOR activation, and that EZH2 ...
A systematic review finds that nanoparticle and liposome delivery systems consistently improve resveratrol's stability and tumor uptake in preclinical models, ...
A new narrative review argues that GLP-1 receptor agonists should be repositioned as foundational cardio-renal-metabolic protectors, with trial evidence extending ...
A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...
A Brazilian cross-sectional study of 96 people with rheumatoid arthritis links more comorbidities, greater pain intensity, lower education, and combination ...
A new review argues that virtual screening and AI-driven modeling have expanded the search for anti-tuberculosis drugs, but persistent mismatches ...
A systematic review and meta-analysis of 20 studies finds that combining intralesional corticosteroids with other therapies is associated with higher ...
A large real-world study in China found that third-generation EGFR inhibitor monotherapy extended progression-free survival in advanced EGFR-mutant lung cancer ...
A review in Genes & Diseases maps how VHL loss drives metabolic reprogramming in clear cell renal cell carcinoma and ...
A new Oncoscience perspective maps the 2025–2026 glioblastoma clinical trial pipeline across four mechanistic domains, showing how biomarker-guided selection and ...
