Machine Learning Identifies Three ALS Progression Patterns
A new machine learning framework identifies three distinct progression patterns in ALS patients, offering a tool for earlier prognostic assessment ...
Tag: amyotrophic lateral sclerosis
Review Evaluates Mesenchymal Stem Cell Immune Modulation to Slow ALS Progression
A review in the Journal of Translational Medicine examines how mesenchymal stem cells may slow amyotrophic lateral sclerosis progression through ...
Deep Learning Model Accelerates Drug Target Screening and Repurposing Opportunities
Researchers have developed a deep learning architecture combining transformers and convolutional neural networks to predict drug-target affinities and accelerate virtual ...
Self-Supervised Deep Learning Classifies Skeletal Muscle Pathology Without Manual Labels
Researchers developed a self-supervised deep learning model that accurately classifies skeletal muscle pathology in mouse models of amyotrophic lateral sclerosis ...
Brain Iron Biomarker Reveals Distinct TDP-43 Pathology Signatures in Aging and Disease
Regional brain ferritin accumulation tracks pathological TDP-43 signatures across aging, Alzheimer's disease, and amyotrophic lateral sclerosis.
Tongue Ultrasound Measurements Correlate With Swallowing Dysfunction in Amyotrophic Lateral Sclerosis
A retrospective case-control study found that reduced tongue thickness measured by ultrasound was associated with swallowing dysfunction in patients with ...
Review Outlines Immune Pathways and Emerging Immunotherapy Strategies in ALS
A review published in Discover Immunity synthesizes evidence on the immunological mechanisms and neuroinflammatory pathways driving amyotrophic lateral sclerosis alongside ...
Differential Tractography Detects Axonal Injury Patterns in Amyotrophic Lateral Sclerosis
Diffusion magnetic resonance imaging with differential tractography identified widespread axonal damage across white matter pathways in amyotrophic lateral sclerosis, most ...
Spinal Cord Vascular Profiling Uncovers Endothelial Dysfunction and Fibroblast Remodeling in ALS
Single-nucleus transcriptomic profiling of human amyotrophic lateral sclerosis tissues reveals marked blood-spinal cord barrier breakdown and specialized perivascular fibroblast remodeling ...
Gut microbes linked to Alzheimer’s, Parkinson’s, Huntington’s and ALS
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Circular RNA circSMOX Emerges as a Player in Muscle and Nerve Disease
A new mini review in Amino Acids summarizes what is known about the circular RNA circSMOX, which is upregulated in ...
HDAC isoform targeting offers a precision route to treating neurodegeneration
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
CSF Protein Signals Stay Stable Through Repeated Freeze-Thaw Cycles in High-Throughput Assay Test
A new evaluation of the Olink Explore 3072 proximity extension assay in cerebrospinal fluid finds that protein detectability and variability ...
Mitochondrial dysfunction emerges as a shared thread across neurological disease
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid ...
Cold-triggered muscle metabolism promotes longevity in worms
Moderately cold temperatures trigger a metabolic pathway in the nematode Caenorhabditis elegans that increases lifespan and supports protein homeostasis, according ...
Tiny Brain Vesicles in Blood Could Transform Diagnosis of Neurological Disease
A new review details how extracellular vesicles carrying brain-derived proteins and RNAs could enable minimally invasive diagnosis of Alzheimer's, Parkinson's, ...
Sample-Preparation Workflow Improves Plasma and CSF Proteomics
A new cost-effective workflow improves proteomic analysis of plasma and cerebrospinal fluid by optimizing protein depletion and digestion for high-throughput ...
AI Models Mine Blood Gene Data to Uncover New ALS Biomarkers
A computational study combining RNA sequencing of blood samples with machine learning and rigorous batch correction has identified 18 candidate ...
POPULAR NEWS
-
Latin American Workers Report Anticipated Labor Vulnerability from Russia-Ukraine War
-
Forage Maize Weeds Attract Beneficial Insects to Support Biological Pest Control
-
Common Medications May Alter Cancer Immunotherapy Outcomes
-
Recombinant GDF15 prophylaxis attenuates cardiorenal toxicity and fibrosis induced by doxorubicin and angiotensin II