AI Models Mine Blood Gene Data to Uncover New ALS Biomarkers
A computational study combining RNA sequencing of blood samples with machine learning and rigorous batch correction has identified 18 candidate ...
Tag: amyotrophic lateral sclerosis
ALS’s ‘Lateral Sclerosis’ Revealed as a Dying-Back Degeneration of Upper Motor Neuron Axons
A clinical-neuropathological study shows that the lateral sclerosis of ALS reflects a length-dependent dying-back degeneration of upper motor neuron axons, ...
TDP-43 Rides Multiple Molecular Motors Along Human Axons, Study Reveals
New research in human neurons shows that the ALS-linked RNA-binding protein TDP-43 is transported along axons by a flexible fleet ...
Astrocytes Drive the Mitochondrial Traffic Jams Behind a Common Form of ALS
New research shows that astrocytes carrying the C9ORF72 mutation disrupt mitochondrial transport in motor neurons through a contact-dependent bioenergetic mechanism ...
ALS Progression Rate Before Diagnosis Fails to Predict Individual Disease Course, Landmark Study Finds
A population-based study of nearly 4,000 ALS patients in Italy shows that the widely used pre-diagnostic ALSFRS-R slope predicts group-level ...
A Simple Nerve Test Could Predict When ALS Patients Will Need Breathing Support
A large pre-registered study shows that the effort-independent amplitude of the phrenic nerve compound muscle action potential predicts the timing ...
Early Weight Loss in ALS Signals Faster Decline, but Standard Energy Formulas Fall Short
A prospective Australian study shows that early weight loss in amyotrophic lateral sclerosis marks a subgroup with faster decline and ...
Clinical Risk Scores Cannot Stand In for Neurofilament Biomarkers in ALS Trials, Study Finds
A reanalysis of the MIROCALS trial shows that the TRICALS clinical risk score adds useful prognostic information in ALS but ...
Poor Sleep May Signal Faster Decline in ALS, Large Chinese Cohort Study Finds
A retrospective cohort study of 268 ALS patients in China found that worse sleep quality on the Pittsburgh Sleep Quality ...
Lactate’s Hidden Switch: How a Once-Dismissed Metabolite Shapes Brain Repair and Degeneration
A new review in the Journal of Translational Medicine details how lactate and protein lactylation act as a double-edged sword, ...
Rare Facial-Onset Nerve Disease Reveals Its Brain Footprint in Advanced MRI Study
Advanced MRI has revealed the first consistent brain signature of the ultra-rare neurological disorder FOSMN, showing brainstem atrophy and damage ...
Spinal Fluid Inflammatory Proteins Reveal Why ALS Progresses at Different Speeds
Researchers profiling inflammatory proteins in cerebrospinal fluid have identified a signature, including SIRT2 and MMP-1, that distinguishes slow from fast ...
TDP-43 Loss Triggers Broad Polyadenylation Shifts in FTD/ALS
In a groundbreaking study published in Nature Neuroscience, researchers have unveiled that the nuclear depletion of the protein TDP-43 in ...
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