Personality Profiles May Shape How APOE Risk Relates to Memory in Middle-Aged Women
In a cross-sectional study of 192 cognitively healthy middle-aged adults, significant associations between APOE and PICALM variants and memory or ...
Tag: Alzheimer’s disease
Crossing the Blood-Brain Barrier Is Only the First Step for CNS Drugs
A new review argues that crossing the blood-brain barrier is only the starting point of CNS drug delivery, with perivascular ...
Research report: Triple network effective connectivity imbalance across the Alzheimer’s disease spectrum and its modulation by intermittent theta burst stimulation
A two-cohort neuroimaging study finds default mode network-centered connectivity imbalance across the Alzheimer's disease spectrum and preliminary evidence that intermittent ...
Lightweight Dual-Branch AI Reads Brain Scans to Spot Alzheimer’s Stages
A lightweight dual-branch AI framework called NeuroCST classified Alzheimer's disease stages from MRI scans with 98.42 percent accuracy while using ...
Gut Microbiota Signals Drive Pericyte Injury and Vascular Damage in Alzheimer’s Mice
A mouse study finds that depleting gut microbiota or neutralizing IL-17A protects cerebrovascular pericytes and the blood-brain barrier in an ...
Cannabidiol shows preclinical promise against Alzheimer’s disease, but key evidence gaps remain
A new review finds cannabidiol consistently reduces neuroinflammation and oxidative stress in Alzheimer's preclinical models, but evidence for amyloid, tau, ...
Sleep disturbance profiles differ across early-stage Alzheimer’s, frontotemporal dementia and Lewy body disease
A prospective Finnish cohort study finds that sleep disturbance profiles differ across early-stage Alzheimer's disease, behavioral variant frontotemporal dementia and ...
Psychobiotics and Fermented Foods May Target the Gut-Brain Axis in Alzheimer’s Disease
A new review finds that psychobiotics and fermented foods show neuroprotective effects in animal models of Alzheimer's disease, while clinical ...
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
Lecanemab shows favorable real-world safety in Korean registry study of 663 patients
A Korean registry study of 663 patients at 32 hospitals found lecanemab had favorable real-world safety, with ARIA in 16.1 ...
Gut Microbiome Signals Track Alzheimer’s Disease, but Treatments Remain Experimental
A new review finds recurring gut microbiome signatures associated with Alzheimer's disease biomarkers, while most microbiome-targeted treatments remain experimental.
Repurposed Drugs and Herbal Compounds Show Early Promise Against Postmenopausal Alzheimer’s in Rat Studies
A systematic review of seventeen rat studies found that repurposed drugs and herbal compounds improved cognition in a postmenopausal Alzheimer's ...
Scientists Say Alzheimer’s Vessel Findings Lack Proof of Function
A PLOS Biology Perspective argues that molecular profiling of brain blood vessels in Alzheimer's disease has outpaced functional measurements, and ...
New study tracks amyloid-beta and blood-brain barrier leakage in CAA
A new protocol study will track longitudinal changes in cerebrospinal fluid amyloid-beta peptides and blood-brain barrier dysfunction in cerebral amyloid ...
Speech-based machine learning detects Alzheimer’s across English and Greek cohorts
An acoustic-only machine-learning pipeline distinguished mild-to-moderate Alzheimer's disease from healthy controls with up to 90.4% mean accuracy across English and ...
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...
Behavioral Changes May Emerge Years Before Cognitive Decline
A study of 11,781 older adults finds that neuropsychiatric symptom trajectories diverge up to 12 years before MCI and 5 ...
Probiotics Show Glimmers of Cognitive Benefit in Dementia Review, but the Evidence Base Is Thin
A systematic review of six randomized trials finds preliminary cognitive gains from probiotics in older adults with existing deficits, while ...
Neuronal SORT1 Protein Shields Brain Cells From Alzheimer’s Damage in New Study
A new study finds that the neuronal protein SORT1 preserves endosomal balance, calms microglial inflammation and improves cognition in Alzheimer's ...
MRI-Based Centiloid Methods Prove Most Reliable for Amyloid PET Scoring
A head-to-head validation in EJNMMI Physics finds MRI-based Centiloid pipelines deliver near-perfect reproducibility for amyloid PET, while PET-only software performance ...
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