Neuronal SORT1 Protein Shields Brain Cells From Alzheimer’s Damage in New Study
A new study finds that the neuronal protein SORT1 preserves endosomal balance, calms microglial inflammation and improves cognition in Alzheimer's ...
Tag: Alzheimer’s disease
MRI-Based Centiloid Methods Prove Most Reliable for Amyloid PET Scoring
A head-to-head validation in EJNMMI Physics finds MRI-based Centiloid pipelines deliver near-perfect reproducibility for amyloid PET, while PET-only software performance ...
Src kinase emerges as a molecular player in early tau pathology in Alzheimer’s disease
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
Acupuncture fMRI Findings Across the Alzheimer’s Continuum: What a Critical Review Reveals
A critical review of BOLD-fMRI studies finds acupuncture-related brain network changes across subjective cognitive decline, mild cognitive impairment, and Alzheimer's ...
Dorsal and ventral hippocampus play distinct roles in memory span and supraspan performance in mice
A new mouse study shows that dorsal and intermediate-ventral hippocampus regions make distinct contributions to memory span and to performance ...
HDAC isoform targeting offers a precision route to treating neurodegeneration
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
Synthetic Receptors Rewired to Sense Amyloid Beta and Release Therapeutics in the Lab
A head-to-head laboratory comparison found that SNIPR and synNotch receptors, but not TRUCKs, supported amyloid beta-dependent expression of therapeutic transgenes ...
Deep learning sharpens ultra-low-dose PET/MR scans in Alzheimer’s disease feasibility study
A retrospective feasibility study reports that a deep learning network substantially improved simulated ultra-low-dose multi-tracer PET/MR images in Alzheimer's disease, ...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Blood–Brain Barrier Breakdown Speeds Alzheimer’s-Like Damage in Fruit Flies
Knocking down the receptor moody in Drosophila barrier glia increased permeability and, together with human amyloid-beta expression, worsened neurodegeneration without ...
Apathy and depression dominate Alzheimer’s symptom networks in early and late disease alike, study finds
A network analysis of 1,360 Alzheimer's patients shows largely overlapping neuropsychiatric symptom networks in early- and late-onset disease, with apathy ...
Blood Test for Early Alzheimer’s Detection Stays Stable Across Storage Conditions
A prospective observational study found that plasma pTau181 measured with the Elecsys Phospho-Tau (181P) immunoassay remained stable across varied sample ...
Plasma exchange cuts amyloid plaques in aged Alzheimer’s model mice
A mouse study reports that monthly plasma exchange with albumin, started at an advanced stage of amyloid pathology, reduced insoluble ...
Federated, explainable AI framework classifies Alzheimer’s disease from MRI and clinical data
A federated learning framework combining MRI and clinical data classifies Alzheimer's disease with reported accuracy up to 94.1 percent while ...
Alzheimer’s Mouse Model Shows Early, Sex-Skewed Skeletal Muscle Decline
A mouse study finds that a triple transgenic Alzheimer's disease model develops measurable skeletal muscle mass, function and innervation deficits ...
New Piperidine Acetamide Compounds Show Early Anti-Alzheimer’s Potential
Researchers in India synthesized five new piperidin-1-yl-phenyl-acetamide derivatives and found that the 2,5-dimethyl compound AS-5 showed the strongest acetylcholinesterase inhibition, ...
AP2A1 emerges as a possible switch between senescence and rejuvenation in human cells
A new review in Discover Aging examines how the AP2A1 protein, long known for its role in clathrin-mediated endocytosis, has ...
Cell Talk at the Blood-Brain Barrier Switches On Insulin Signaling
Co-culturing human brain endothelial cells with pericytes activates AKT and ERK insulin signaling, raises TIMP1 and collagen-IV, inhibits MMP activity ...
Stem cell therapies show promise for Alzheimer’s disease, but clinical evidence remains limited
A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical ...
Research report: Short-interval variability and test-retest reliability of Alzheimer’s disease plasma biomarkers in a clinically heterogenous cohort
A UCL study of 92 participants found core Alzheimer's plasma biomarkers showed high test-retest reliability over intervals from 30 minutes ...
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