Tag: Alzheimer’s disease

A new review in Molecular Biology Reports synthesizes in vitro, animal, and clinical evidence on six molecular mechanisms by which ...

A study of 409 participants found that sleep-disordered breathing is associated with elevated cerebrospinal fluid markers of blood-brain barrier dysfunction ...

A five-year NIH grant will support research examining how sleep health, lipid-derived inflammatory mediators, and neighborhood conditions influence cognitive decline ...

A narrative review in Genes and Environment finds that the APOE ε4 allele's risk for Alzheimer's disease is less pronounced ...

A study in EMBO Reports reports that mitochondrial APP and Aβ40 are associated with reduced CerS1/C18-ceramide accumulation and mitophagy readouts ...

A cross-sectional cohort study reveals that Alzheimer's disease co-pathology in dementia with Lewy bodies is linked to stage-dependent visual impairments ...

A new study links smoking-associated cadmium to JNK2 activation in neurons, driving mitochondrial dysfunction and APP accumulation relevant to Alzheimer's ...

In a preclinical study using 5xFAD mice, five-hertz sinusoidal amplitude-modulated focused ultrasound normalized aberrant hippocampal oscillations and improved learning and ...

A meta-analysis of eighteen studies found that African American participants had significantly lower tau and neurodegeneration biomarker levels in cerebrospinal ...

Researchers have developed DIRAC, a geometric deep learning model that aligns distinct molecular modalities and transfers cell annotations across diverse ...

A systematic review details how combining cerebrospinal fluid, blood, and saliva biomarkers establishes an accessible biological framework for diagnosing and ...

A new review argues that acetylcholinesterase acts beyond breaking down acetylcholine, accelerating amyloid-beta aggregation and tau pathology while remaining a ...

A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...

A blood test for tau protein fragments predicted Alzheimer's cognitive symptoms nearly as accurately as autopsy-confirmed brain pathology in a ...

A study of 1,546 patients with biomarker-confirmed symptomatic Alzheimer's disease found that 35 carriers of rare high-risk SORL1 variants showed ...

A narrative review indicates that blood-brain barrier disruption in Alzheimer's disease increases cerebral antipsychotic penetration, triggering parkinsonian side effects and ...

Researchers have discovered that the ciliary p75 neurotrophin receptor mediates amyloid beta accumulation and oxidative stress in human hippocampal astrocytes.

A multimodal neuroimaging and transcriptomic study across the Alzheimer's disease continuum found that regional brain synchronization abnormalities are consistently associated ...

Human microglia fail to degrade extracellular tau, instead recycling internalized monomers back into the surrounding space and anchoring inflammatory fibrils ...

A new review proposes matching lipid nanoparticle designs to specific Alzheimer's disease pathways, from neuronal BACE1 siRNA delivery to microglia-targeted ...