Ultrasensitive profiling of neuron- and astrocyte-derived vesicles from plasma reveals stage-linked protein signatures of neurodegeneration, inflammation and vascular stress across ...
A computational study from the University of Kalyani predicts the structural features of Aβ175, a protein encoded by the circular ...
Adults with obesity who achieved major weight loss over one year showed increased subcortical gray matter volume and improved metabolic ...
A mouse study finds that photobiomodulation improves learning and amyloid beta clearance in young and middle-aged animals, but not in ...
In Alzheimer-model mice, minimally invasive vagus nerve stimulation delivered right after orthopedic surgery reduced acute amyloid-beta accumulation, neuronal loss and ...
De novo designed microproteins, built computationally to bind toxic amyloid fibrils and restore mitochondrial function, are emerging as promising candidates ...
A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.
A new PLOS Biology Editorial argues that neurodegeneration research must look beyond dying neurons to the glia, vasculature, immune signals ...
A new study reports that CADM3 expression drops in human Alzheimer's brains and that its genetic loss worsens amyloid deposition, ...
A two-cohort study finds that CSF synaptic biomarkers rise with tau pathology but stay near baseline when amyloid plaques appear ...
A new commentary proposes that the mitochondrial protein PINK1, a central regulator of mitophagy, could act as a direct amyloid ...
Icariin, the main bioactive component of Herba Epimedii, reversed nucleolar stress markers in Aβ25–35-treated BV2 cells and APP/PS1 mice, according ...
A review integrates associative observations in patients with Alzheimer's disease and mild cognitive impairment alongside experimental and animal findings on ...
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive ...
A new mouse study shows that traumatic brain injury alone triggers early Alzheimer-like protein variant buildup in wild-type animals, and ...
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...
![Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer's drug design](https://bioengineer.org/wp-content/uploads/2026/10/stackrss-featured-24177-350x250.png)
A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing ...
A longitudinal PET and fMRI study links two distinct microglial activation signatures, structured by functional brain connectivity, to the spatial ...
